Dopamine transporter imaging does not predict the number of nigral neurons in Parkinson disease
Dopamine transporter imaging does not predict the number of nigral neurons in Parkinson disease
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DOI：
10.1212/wnl.0000000000003810
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发表时间：
2017-04-11
期刊：
影响因子：
9.9
通讯作者：
Kaasinen, Valtteri
中科院分区：
文献类型：
--
作者：
Saari, Laura;Kivinen, Katri;Kaasinen, Valtteri
目的：探讨帕金森病（PD）患者体内脑多巴胺转运体SPECT成像与黑质致密部（SNc）神经元存活的关系。方法：采用多巴胺转运体（DAT） SPECT对18例患者（其中11例为神经病理证实的PD患者）进行死亡前神经神经元数量的计算。采用基于兴趣的半定量区域和基于体素的分析，分析SNc酪氨酸羟化酶（TH）阳性和含有神经黑色素的神经元计数与DAT纹状体特异性结合比（sbr）之间的相关性。结果：平均壳核SBR与黑质th阳性（r =0.11, p = 0.66）或含神经黑色素（r = -0.07, p = 0.78）神经元数量无关。当使用SPECT与死亡之间的时间间隔作为协变量时，当使用基于体素的分析时，当仅包括PD患者时，相关性仍然明显不显著。结论：该队列研究表明，PD患者死后SNc神经元计数与纹状体数据结合无关。这些结果符合在一定程度的损伤发生后，黑质神经元数量与纹状体多巴胺之间没有相关性的理论。PD的纹状体DAT结合可能反映轴突功能障碍或DAT表达，而不是活神经元的数量。
Objective: To examine possible associations between in vivo brain dopamine transporter SPECT imaging and substantia nigra pars compacta (SNc) neuronal survival in Parkinson disease (PD).Methods: Nigral neuron numbers were calculated for 18 patients (11 patients with neuropathologically confirmed PD) who had been examined with dopamine transporter (DAT) SPECT before death. Correlation analyses between SNc tyrosine hydroxylase (TH)-positive and neuromelanincontaining neuron counts and DAT striatal specific binding ratios (SBRs) were performed with semiquantitative region of interest-based and voxel-based analyses.Results: Mean putamen SBR did not correlate with the number of substantia nigra TH-positive (r = =0.11, p = 0.66) or neuromelanin-containing (r = -0.07, p = 0.78) neurons. Correlations remained clearly nonsignificant when the time interval between SPECT and death was used as a covariate, when the voxel-based analysis was used, and when only patients with PD were included.Conclusions: This cohort study demonstrates that postmortem SNc neuron counts are not associated with striatal DAT binding in PD. These results fit with the theory that there is no correlation between the number of substantia nigra neurons and striatal dopamine after a certain level of damage has occurred. Striatal DAT binding in PD may reflect axonal dysfunction or DAT expression rather than the number of viable neurons.