RANDOMIZED CONTROLLED TRIAL OF EFFICACY OF ALBENDAZOLE IN INTRAABDOMINAL HYDATID-DISEASE
RANDOMIZED CONTROLLED TRIAL OF EFFICACY OF ALBENDAZOLE IN INTRAABDOMINAL HYDATID-DISEASE
复制标题
DOI：
10.1016/0140-6736(93)92361-v
复制
发表时间：
1993-11-20
期刊：
影响因子：
168.9
通讯作者：
DALRE, R
中科院分区：
文献类型：
--
作者：
GILGRANDE, LA;RODRIGUEZCAABEIRO, F;DALRE, R
阿苯达唑治疗包虫病的疗效尚不清楚，因为还没有研究评估治疗后寄生虫的状态。因此，阿苯达唑引起的囊肿回声改变的意义无法判断。我们做了一个前瞻性的，对照的，随机的，开放的研究，阿苯达唑在肝包虫病患者，并评估治疗后的寄生虫活力。18例患者没有接受阿苯达唑治疗（对照组），18个接受阿苯达唑（10 mg/kg每日）1个月（A组），19个接受药物约3个月（B组）。在治疗前和治疗期间进行回波描记术;所有患者完成手术。寄生虫（原头节活力和发展的囊肿在小鼠）和超微结构的研究进行了所有的囊肿去除。对照组中8例（50%）囊肿、A组中13例（72%）囊肿和B组中16例（94%）囊肿无活力（p=0.015）。治疗患者的原头节和囊肿活力显著（分别为p=0.039和p=0.018）低于对照组。治疗也与总囊膜崩解显著相关。68%的囊肿治疗3个月显示回声改变，只有1/20的囊肿显示回声改变在治疗过程中被判定为living.The疗效阿苯达唑在10毫克/公斤，每天3个月的剂量表明，它是一个合适的替代手术简单的包虫病，作为初始治疗。
The efficacy of albendazole in hydatid disease is still unclear, because there has been no study that assessed the status of the parasite after treatment. The significance of albendazole-induced echographic changes in the cyst therefore cannot be judged. We did a prospective, controlled, randomised, open study of albendazole in patients with liver hydatid disease, and assessed parasite viability after treatment.18 patients received no albendazole treatment (controls), 18 received albendazole (10 mg/kg daily) for 1 month (group A), and 19 received the drug for about 3 months (group B). Echography was done before and during treatment; all patients underwent surgery on completion. Parasite (protoscolex viability and development of cysts in mice) and ultrastructure studies were done for all cysts removed. 8 (50%) of cysts in the control group, 13 (72%) in group A, and 16 (94%) in group B were non-viable (p=0.015). Protoscolex and cyst viability were significantly (p=0.039 and p=0.018, respectively) lower in treated patients than in controls. Treatment was also significantly associated with total cyst membrane disintegration. 68% of cysts treated for 3 months showed echographic changes, and only 1 of 20 cysts showing echographic changes during treatment was judged viable.The efficacy of albendazole at a dose of 10 mg/kg daily for 3 months suggests that it is a suitable alternative to surgery in uncomplicated hydatid liver disease, as initial treatment.