Frequency and intensity response properties of single neurons in the auditory cortex of the behaving macaque monkey
Frequency and intensity response properties of single neurons in the auditory cortex of the behaving macaque monkey
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DOI：
10.1152/jn.2000.83.4.2315
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发表时间：
2000-04-01
影响因子：
2.5
通讯作者：
Phan, ML
中科院分区：
文献类型：
--
作者：
Recanzone, GH;Guard, DC;Phan, ML
在麻醉制剂中测量的听觉皮层神经元的反应特性为不同听觉皮层区域神经元之间的生理差异提供了重要信息。然而，对清醒动物的研究却不太常见，所注意到的生理差异可能反映了麻醉剂对不同皮质区域神经元影响的差异。由于行为猴作为动物模型在探索听觉皮层功能的研究中越来越受欢迎，因此从生理学角度定义该制剂中听觉皮层神经元的反应特性变得至关重要。这项研究记录了执行听觉辨别任务的猴子的初级和周围听觉皮层区域中单个皮质神经元的反应特性。我们发现潜伏期最短的神经元位于初级听觉皮层（AI）。在所研究的四个皮层区域中，头侧神经元具有最长的潜伏期和最窄的强度和频率调谐，尾内侧区域的神经元具有最宽的频率调谐，侧区域的神经元具有最单调的速率/水平函数。这些趋势是通过比较所研究的神经元群体的响应特性来揭示的，但是每个皮层区域中除了特征频率（CF）之外的每个响应参数的神经元之间存在相当大的变异性。尽管神经元 CF 显示出整个 AI 的系统性空间组织，但对于 AI 或邻近皮质区域的任何其他反应特性来说，这种系统性组织并不明显。这项研究的结果表明，行为猴的听觉皮层区域之间存在生理差异，这与之前对麻醉动物的研究一致，并为这些皮层区域在处理声音信息中的功能作用提供了见解。
Response properties of auditory cortical neurons measured in anesthetized preparations have provided important information on the physiological differences between neurons in different auditory cortical areas. Studies in the awake animal, however, have been much less common, and the physiological differences noted may reflect differences in the influence of anesthetics on neurons in different cortical areas. Because the behaving monkey is gaining popularity as an animal model in studies exploring auditory cortical function, it has become critical to physiologically define the response properties of auditory cortical neurons in this preparation. This study documents the response properties of single cortical neurons in the primary and surrounding auditory cortical fields in monkeys performing an auditory discrimination task. We found that neurons with the shortest latencies were located in the primary auditory cortex (AI). Neurons in the rostral held had the longest latencies and the narrowest intensity and frequency tuning, neurons in the caudomedial field had the broadest frequency tuning, and neurons in the lateral field had the most monotonic rate/level functions of the four cortical areas studied, These trends were revealed by comparing response properties across the population of studied neurons, but there was considerable variability between neurons for each response parameter other than characteristic frequency (CF) in each cortical area. Although the neuronal CFs showed a systematic spatial organization across AI, no such systematic organization was apparent for any other response property in AI or the adjacent cortical areas. The results of this study indicate that there are physiological differences between auditory cortical fields in the behaving monkey consistent with previous studies in the anesthetized animal and provide insights into the functional role of these cortical areas in processing acoustic information.