Adjusting the mechanical behavior of embroidered scaffolds to lapin anterior cruciate ligaments by varying the thread materials
Adjusting the mechanical behavior of embroidered scaffolds to lapin anterior cruciate ligaments by varying the thread materials
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DOI：
10.1177/0040517514566107
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发表时间：
2015-09-01
影响因子：
2.3
通讯作者：
Heinrich, Gert
中科院分区：
文献类型：
--
作者：
Hahner, Judith;Hinueber, Claudia;Heinrich, Gert
前交叉韧带（ACL）的创伤性断裂可导致局部不稳定和活动性丧失。由于材料选择和力学性能欠佳，使用工程化ACL移植物进行重建很少成功。因此，所提出的工作证明了制造的各种刺绣单和双组分支架制成的两个市售的单丝（聚对二氧环己酮，聚（乳酸-共-己内酯）），以及一种新型的熔纺聚（L-乳酸）复丝和它们的机械分析拉伸试验和循环载荷下。通过材料组成和织物参数调整的所选支架显示出与天然膝关节ACL组织相当的载荷-应变行为，其在脚趾区域内表现出1.7%的足够量的弹性变形、123 N/mm的支架刚度和足够的最大拉伸载荷（300 N）和应变（20%）。因此，可吸收刺绣双组分支架的设计代表了替代人工不可吸收韧带移植物的有前途的方法，并允许创新的组织工程策略。
Traumatic rupture of the anterior cruciate ligament (ACL) can cause local destabilization and loss of mobility. Reconstruction using engineered ACL grafts is rarely successful due to sub-optimal material choice and mechanical performance. Thus, the presented work demonstrates the fabrication of various embroidered single- and bi-component scaffolds made of two commercially available monofilament threads (polydioxanone, poly(lactic acid-co-- caprolactone)) as well as a novel melt spun poly(L-lactic acid) multifilament and their mechanical analysis by tensile tests and under cyclic loading. Selected scaffolds, adjusted by material composition and textile parameters, revealed a load-strain behavior comparable to native lapin ACL tissue exhibiting a sufficient amount of elastic deformation within the toe-region of 1.7%, scaffold stiffness of 123 N/mm and adequate maximum tensile load (300 N) and strain (20%). Therefore, the design of resorbable embroidered bi-component scaffolds represents a promising approach to replace artificial non-resorbable ligament grafts and allows for innovative tissue engineering strategies.