Local and regional wave speed in the aorta: effects of arterial occlusion
Local and regional wave speed in the aorta: effects of arterial occlusion
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DOI：
10.1016/j.medengphy.2003.08.004
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发表时间：
2004-01-01
影响因子：
2.2
通讯作者：
Parker, KH
中科院分区：
文献类型：
--
作者：
Khir, AW;Zambanini, A;Parker, KH
动脉波速度广泛用于确定动脉扩张性，并已被用作血管疾病的替代标志物。本文的主要目标之一是将传统的英尺对英尺波速测量方法与压力速度环（PU 环）方法的结果进行比较。我们还研究了沿主动脉的区域波速，以及动脉闭塞对升主动脉中测量的 PU 环的影响。在 11 只麻醉狗中，在四个部位产生持续 3 分钟的完全闭塞：上胸动脉、膈动脉、腹动脉和左髂动脉。测量升主动脉的压力和流量以及闭塞部位近端的压力，并在闭塞之前、闭塞期间和闭塞移除之后收集数据。在控制条件下，主动脉根部 PU 环确定的波速系统地低于通过脚对脚法测量的波速。在胸廓和膈肌闭塞期间，平均主动脉压和波速显着增加，但在每次闭塞移除后恢复到控制值。 PU 环是一种客观且易于使用的确定波速的方法，当可进行局部压力和速度测量时，有利于在短动脉段中使用。 (C) 2003 年 IPEM。由爱思唯尔有限公司出版。保留所有权利。
Arterial wave speed is widely used to determine arterial distensibility and has been utilised as a surrogate marker for vascular disease. A comparison between the results of the traditional foot-to-foot method for measuring wave speed to those of the pressure-velocity loop (PU-loop) method is one of the primary objectives of this paper. We also investigate the regional wave speed along the aorta, and the effect of arterial occlusion on the PU-loop measured in the ascending aorta. In 11 anaesthetised dogs, a total occlusion lasting 3 min was produced at four sites: upper thoracic, diaphragm, abdominal and left iliac artery. Pressure and flow in the ascending aorta and pressure proximal to the occlusion site were measured, and data were collected before, during the occlusion and after the occlusion had been removed. In control conditions, the wave speeds determined by the PU-loop in the aortic root were systematically lower than those measured by the foot-to-foot method. During thoracic and diaphragm occlusions, mean aortic pressure and wave speed increased significantly but returned to control values after each occlusion had been removed. The PU-loop is an objective and easy to use method for determining wave speed and can be advantageous for use in short arterial segments when local measurements of pressure and velocity are available. (C) 2003 IPEM. Published by Elsevier Ltd. All rights reserved.