β-Cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans
β-Cell replication is the primary mechanism subserving the postnatal expansion of β-cell mass in humans
复制标题
DOI：
10.2337/db07-1369
复制
发表时间：
2008-06-01
期刊：
影响因子：
7.7
通讯作者：
Butler, Peter C.
中科院分区：
文献类型：
--
作者：
Meier, Juris J.;Butler, Alexandra E.;Butler, Peter C.
关于人类β细胞群生长的能力、机制或时间，我们知之甚少。我们试图确定人类β细胞群的主要扩增是否发生在幼儿期，以及是否与啮齿动物一样，这与相对丰富的β细胞复制相吻合。我们还试图建立是否有一个与青春期加速体细胞生长相一致的β细胞团的二次生长。研究设计和方法-为了解决这些问题，胰腺体积由135名4周到20岁的儿童的腹部计算机断层扫描确定，对46例年龄在2周到21岁之间的儿童尸检时获得的人胰腺组织进行了形态计量学分析。2）在此过渡期间，胰岛在大小上而不是在数量上生长，3）β细胞生长的相对速率在婴儿期最高，此后逐渐下降至成年期，没有第二加速生长期（引诱青春期，4）β细胞质量（以及大概的生长）在个体之间是高度可变的，和5）高速率的β细胞复制与β细胞群的主要出生后扩张相一致。这些数据表明，在婴儿期β细胞复制的调节在成人β细胞群中起着重要作用。
OBJECTIVE-Little is known about the capacity, mechanisms, or timing of growth in beta-cell mass in humans. We sought to establish if the predominant expansion of beta-cell mass in humans occurs in early childhood and if, as in rodents, this coincides with relatively abundant beta-cell replication. We also sought to establish if there is a secondary growth in beta-cell mass coincident with the accelerated somatic growth in adolescence.RESEARCH DESIGN AND METHODS-To address these questions, pancreas volume was determined from abdominal computer tomographies in 135 children aged 4 weeks to 20 years, and morphometric analyses were performed in human pancreatic tissue obtained at autopsy from 46 children aged 2 weeks to 21 years.RESULTS-We report that 1) beta-cell mass expands by several-fold from birth to adulthood, 2) islets grow in size rather than in number during this transition, 3) the relative rate of beta-cell growth is highest in infancy and gradually declines thereafter to adulthood with no secondary accelerated growth phase (luring adolescence, 4) beta-cell mass (and presumably growth) is highly variable between individuals, and 5) a high rate of beta-cell replication is coincident with the major postnatal expansion of beta-cell mass.CONCLUSIONS-These data imply that regulation of beta-cell replication during infancy plays a major role in beta-cell mass in adult humans.