Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
Gut microbiota composition and functional changes in inflammatory bowel disease and irritable bowel syndrome
复制标题
DOI：
10.1126/scitranslmed.aap8914
复制
发表时间：
2018-12-19
影响因子：
17.1
通讯作者：
Weersma, Rinse K.
中科院分区：
文献类型：
--
作者：
Vila, Arnau Vich;Imhann, Floris;Weersma, Rinse K.
肠道菌群的变化与两种最常见的胃肠道疾病，炎症性肠病（IBD）和肠易激综合征（IBS）有关。在这里，我们使用霰弹枪宏基因组测序对来自1792名IBD和IBS患者的粪便样本进行了病例对照分析，并与普通人群中的对照组进行了比较。尽管与对照组相比，IBD和IBS患者的肠道微生物组存在大量重叠，但我们能够使用肠道微生物群组成差异来区分IBD患者和IBS患者。通过结合菌种水平和菌株水平与细菌生长速率、代谢功能、抗生素耐药性和毒力因子分析，我们确定了可能与两种常见胃肠道疾病有关的关键细菌种类。
Changes in the gut microbiota have been associated with two of the most common gastrointestinal diseases, inflammatory bowel disease (IBD) and irritable bowel syndrome (IBS). Here, we performed a case-control analysis using shotgun metagenomic sequencing of stool samples from 1792 individuals with IBD and IBS compared with control individuals in the general population. Despite substantial overlap between the gut microbiome of patients with IBD and IBS compared with control individuals, we were able to use gut microbiota composition differences to distinguish patients with IBD from those with IBS. By combining species-level profiles and strain-level profiles with bacterial growth rates, metabolic functions, antibiotic resistance, and virulence factor analyses, we identified key bacterial species that may be involved in two common gastrointestinal diseases.