EFFECTS OF PCO2 ACETAZOLAMIDE AND OUABAIN ON VOLUME AND COMPOSITION OF CHOROID-PLEXUS FLUID
EFFECTS OF PCO2 ACETAZOLAMIDE AND OUABAIN ON VOLUME AND COMPOSITION OF CHOROID-PLEXUS FLUID
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DOI：
10.1113/jphysiol.1965.sp007780
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发表时间：
1965-01-01
影响因子：
5.5
通讯作者：
NESBETT, FB
中科院分区：
文献类型：
--
作者：
AMES, A;HIGASHI, K;NESBETT, FB
通过过度通气降低动脉Pco 2可降低脉络丛液体形成率，而不改变其电解质组成。吸入10%CO2升高动脉Pco 2可增加脉络丛液体的形成率，并使其Na+和Cl-浓度之间的差异增加9 m [image]，可能反映了HCO 3-的升高;脉络丛液体K +没有变化。改变脉络丛CSF侧的Pco 2对正在形成的流体的电解质组成几乎没有影响。局部应用乙酰唑胺或哇巴因导致脉络丛液体形成率显著下降。乙酰唑胺不影响其电解质组成，但哇巴因引起脉络丛液K+增加55%。
Reduction of arterial Pco2 by hyperventilation reduced the rate of choroid-plexus fluid formation without changing its electrolyte composition. Elevation of arterial Pco2 by 10% CO2 inhalation increased the rate of choroid-plexus fluid formation and increased by 9m[image] the difference between its Na+ and Cl- concentrations, reflecting presumably a rise in HCO3 -; there was no change in the choroid-plexus fluid K +. Changing Pco2 on the CSF side of the choroid plexus had little effect on the electrolyte composition of the fluid being formed. Topical application of either acetazolamide or ouabain caused a marked fall in the rate of choroid-plexus fluid formation. Acetazolamide did not affect its electrolyte composition but ouabain caused a 55% increase in the choroid-plexus fluid K+.