Diffusion Tensor Imaging Findings in School-Aged Autistic Children
Diffusion Tensor Imaging Findings in School-Aged Autistic Children
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DOI：
10.1111/j.1552-6569.2009.00366.x
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发表时间：
2009-10-01
影响因子：
2.4
通讯作者：
Pinto Calcada, Carlos Adolfo B.
中科院分区：
文献类型：
--
作者：
Brito, Adriana Rocha;Vasconcelos, Marcio Moacyr;Pinto Calcada, Carlos Adolfo B.
分析和比较大脑白色物质束通过扩散张量成像在自闭症和normal children. METHODS这是一个病例对照研究的样本8名男性，右撇子儿童诊断为自闭症根据诊断和统计手册精神障碍-第4版标准，和8个健康的年龄和性别匹配的对照。在1.5 T扫描仪（Symphony Maestro Class，Siemens，埃尔兰根，德国）上进行成像研究。计算额桥和皮质脊髓束、额叶皮质下白色物质、前扣带回、胼胝体、纹状体、内囊、视放射、上级和下级纵束以及小脑的各向异性分数。显著性分析是基于对平均各向异性分数值的方差分析。病例组和对照组的平均年龄分别为9.53 ± 1.83岁和9.57 ± 1.36岁。扩散张量成像结果包括胼胝体前部各向异性分数显著降低（P = .008），右侧皮质脊髓束（P = 0.044），左右内囊后肢（P分别为0.003和0.049），左上级小脑脚（P = .031），以及右侧和左侧中小脑脚（P = 0.043和0.039）。结论自闭症儿童的弥散张量成像结果表明白色物质微结构受损，可能与胼胝体、内囊、小脑上级和中脚的连接性降低有关。J Neuroimaging 2009;19：337-343。
OBJECTIVETo analyze and compare cerebral white matter tracts through diffusion tensor imaging in autistic and normal children.METHODSThis is a case-control study on a sample of eight male, right-handed children diagnosed with autism according to Diagnostic and Statistical Manual of Mental Disorders-4th Edition criteria, and eight healthy age- and sex-matched controls. Imaging studies were performed on a 1.5-T scanner (Symphony Maestro Class, Siemens, Erlangen, Germany). Fractional anisotropy was calculated for the frontopontine and corticospinal tracts, frontal subcortical white matter, anterior cingulate, corpus callosum, striatum, internal capsule, optic radiation, superior and inferior longitudinal fascicles, and cerebellum. Analysis of significance was based on analysis of variance test for the mean fractional anisotropy values.RESULTSMedian age of cases was 9.53 +/- 1.83 years, and of controls, 9.57 +/- 1.36 years. Diffusion tensor imaging findings included significant reduction of fractional anisotropy in the anterior corpus callosum (P = .008), right corticospinal tract (P = .044), posterior limb of right and left internal capsules (P = .003 and .049, respectively), left superior cerebellar peduncle (P = .031), and right and left middle cerebellar peduncles (P = .043 and .039, respectively) in autistic children.CONCLUSIONSThe diffusion tensor imaging findings in children with autistic disorder suggest impairment of white matter microstructure, possibly associated with reduced connectivity in corpus callosum, internal capsule, and superior and middle cerebellar peduncles.J Neuroimaging 2009;19:337-343.