Infusion of the dopamine D1 receptor antagonist SCH 23390 into the amygdala blocks fear expression in a potentiated startle paradigm
Infusion of the dopamine D1 receptor antagonist SCH 23390 into the amygdala blocks fear expression in a potentiated startle paradigm
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DOI：
10.1016/s0006-8993(98)00281-9
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发表时间：
1998-06-08
期刊：
影响因子：
2.9
通讯作者：
Kokkinidis, L
中科院分区：
文献类型：
--
作者：
Lamont, EW;Kokkinidis, L
多巴胺 (DA) D-1 受体分布在伏隔核和杏仁核中，这两个中皮质边缘 DA 系统区域已知会被厌恶的环境刺激激活。本研究的目的是确定这些大脑区域中的 D-1 受体对恐惧引发的行为（尤其是大鼠的强化惊吓）表达的贡献。将 DA D-1 受体拮抗剂 SCH 23390 注射到杏仁核中，可阻断先前与足部电击配对的条件光刺激增强声惊吓幅度的能力。双侧脑内向伏隔核注射 SCH 23390 对恐惧增强惊吓没有影响。观察到的杏仁核 DA D-1 受体拮抗作用对恐惧表达的相反作用，以及早期研究证明腹侧被盖区 (VTA) DA 神经元参与恐惧增强惊吓，表明中杏仁核活动在条件性兴奋性恐惧反应中发挥作用。 (C) 1998 Elsevier Science B.V. 保留所有权利。
Dopamine (DA) D-1 receptors are distributed in the nucleus accumbens and the amygdala, two regions of the mesocorticolimbic DA system known to be activated by aversive environmental stimuli. The objective of the present study was to determine the contribution of D-1 receptors in these brain regions to the expression of a fear-motivated behavior, notably, potentiated startle in rats. Injection of the DA D-1 receptor antagonist SCH 23390 into the amygdala blocked the ability of a conditioned light stimulus previously paired with footshock to enhance acoustic startle amplitudes. Bilateral intracerebral administration of SCH 23390 into the nucleus accumbens had no effect on fear-potentiated startle. The observed opposing effects of amygdaloid DA D-1 receptor antagonism on fear expression, along with earlier research demonstrating the involvement of ventral tegmental area (VTA) DA neurons on fear-potentiated startle, suggest a role for mesoamygdaloid activity in conditioned excitatory fear reactions. (C) 1998 Elsevier Science B.V. All rights reserved.