Effect of fortified complementary food supplementation on child growth in rural Bangladesh: a cluster-randomized trial
Effect of fortified complementary food supplementation on child growth in rural Bangladesh: a cluster-randomized trial
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DOI：
10.1093/ije/dyv155
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发表时间：
2015-12-01
影响因子：
7.7
通讯作者：
West, Keith P., Jr.
中科院分区：
文献类型：
--
作者：
Christian, Parul;Shaikh, Saijuddin;West, Keith P., Jr.
背景：在南亚，婴儿出生后头2年的生长迟缓率很高，那里的发育迟缓率估计为40- 50%。虽然营养咨询显示出一定的益处，但很少有食物补充的干预试验显示出生长和预防发育迟缓的改善。在孟加拉国农村进行了一项随机分组对照试验，以测试两种当地即食食品的效果（鹰嘴豆和大米扁豆为基础）和强化混合食品（小麦-大豆-混合物++，WSB++）与Pluelos 'doz相比，所有营养咨询与单独营养咨询（对照）对线性增长的结果在6-18月龄的儿童中，测量身高和身高-年龄z-评分（LAZ）、发育迟缓（LAZ< 2）、体重-身高z-评分（WLZ）和消瘦（WLZ< -2）。儿童（n = 5536）在6个月大时入组，在食物组中，每天提供一种分配的补充剂，持续一年。生长减速发生在6 ~ 18月龄，但LAZ的减速较低与对照组相比，在Pluelloz 'doz（P = 0.02）、水稻-扁豆（< 0.01）和鹰嘴豆（< 0.01）组中，WLZ下降（0.02-0.04/月），而WLZ下降仅在Pluelloz'doz和鹰嘴豆组中较低。WSB++对这些结果没有影响。对照组18个月时发育迟缓发生率为44%，但比对照组低5-6%（P
Background: Growth faltering in the first 2 years of life is high in South Asia where prevalence of stunting is estimated at 40-50%. Although nutrition counselling has shown modest benefits, few intervention trials of food supplementation exist showing improvements in growth and prevention of stunting.Methods: A cluster-randomized controlled trial was conducted in rural Bangladesh to test the effect of two local, ready-to-use foods (chickpea and rice-lentil based) and a fortified blended food (wheat-soy-blend++, WSB++) compared with Plumpy'doz, all with nutrition counselling vs nutrition counselling alone (control) on outcomes of linear growth (length and length-for-age z-score, LAZ), stunting (LAZ< 2), weight-for-length z-score (WLZ) and wasting (WLZ< -2) in children 6-18 months of age. Children (n = 5536) were enrolled at 6 months of age and, in the food groups, provided with one of the allocated supplements daily for a year.Results: Growth deceleration occurred from 6 to 18 months of age but deceleration in LAZ was lower (by 0.02-0.04/month) in the Plumpy'doz (P = 0.02), rice-lentil (< 0.01), and chickpea (< 0.01) groups relative to control, whereas WLZ decline was lower only in Plumpy'doz and chickpea groups. WSB++ did not impact on these outcomes. The prevalence of stunting was 44% at 18 months in the control group, but lower by 5-6% (P