Aberrant interleukin-2 receptor-mediated blastoformation of peripheral blood lymphocytes in a severe major depressive episode
Aberrant interleukin-2 receptor-mediated blastoformation of peripheral blood lymphocytes in a severe major depressive episode
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DOI：
10.1017/s0033291797006454
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发表时间：
1998-03-01
影响因子：
6.9
通讯作者：
Asai, M
中科院分区：
文献类型：
--
作者：
Kanba, S;Manki, H;Asai, M
背景。我们研究了抑郁症中与白细胞介素-2 （IL-2）相关的免疫通路，以阐明抑郁症相关的各种免疫紊乱的机制。受试者包括35名未服药且无精神病特征的重度抑郁发作患者和36名年龄和性别匹配的健康志愿者。免疫指标包括B细胞和T细胞数量、IL-2受体介导的囊胚形成（il - 2r介导的囊胚形成）、IL-2的产生和IL-2受体α亚基的表达。严重发作的患者il - 2r介导的囊胚形成明显低于对照组。il - 2r介导的囊胚形成与入组时抑郁严重程度呈显著负相关。il - 2r介导的囊胚形成减少可能部分解释了先前报道的与抑郁症相关的几种异常免疫功能。
Background. We examined interleukin-2 (IL-2) related immune pathways in depression to elucidate mechanisms underlying various immunological disturbances associated with depression.Methods. Subjects comprised 35 unmedicated patients with a major depressive episode without psychotic features and 36 age-and sex-matched healthy volunteers. The immune parameters examined included the numbers of B and T cells, IL-2 receptor-mediated blastoformation (IL-2R-mediated blastoformation), IL-2 production and expression of the IL-2 receptor alpha-subunit.Results. The patients with a severe episode showed significantly lower IL-2R-mediated blastoformation than the controls. There was a statistically significant negative correlation between IL-2R-mediated blastoformation and the severity of depression at the time of entry.Conclusion. The reduced IL-2R-mediated blastoformation may partly explain several previously reported abnormal immune functions associated with depression.