European Code against Cancer 4th Edition: Obesity, body fatness and cancer
European Code against Cancer 4th Edition: Obesity, body fatness and cancer
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DOI：
10.1016/j.canep.2015.01.017
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发表时间：
2015-12-01
影响因子：
2.6
通讯作者：
Romieu, Isabelle
中科院分区：
文献类型：
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作者：
Anderson, Annie S.;Key, Timothy J.;Romieu, Isabelle
据估计，由于能量消耗和能量摄入之间的不平衡，欧洲联盟（EU）超过一半的人口超重或肥胖;这与控制体重的社会文化，经济和市场挑战的致肥环境有关。过多的身体脂肪与九个癌症部位有关-食道，结肠直肠，胆囊，胰腺，绝经后乳腺，子宫内膜，卵巢，肾脏和前列腺（晚期）-这些癌症中的4-38%（取决于部位和性别）可归因于超重/肥胖状态。伴随着超重的代谢改变伴随着炎症、胰岛素、雌激素和其他激素因子水平的增加。有一些迹象表明，有意减肥与降低癌症发病率有关（特别是在绝经后乳腺癌和子宫内膜癌中）。超重也是其他几种疾病的危险因素，包括糖尿病和心脏病，并与过早死亡的风险较高有关。在审查目前与过量身体脂肪和癌症有关的证据时，欧洲癌症营养工作组制定了以下建议：“采取行动保持健康的体重”。(C)2015年国际癌症研究机构;被许可人ELSEVIER Ltd
It is estimated that over half the population of the European Union (EU) is overweight or obese due to an imbalance between energy expenditure and energy intake; this is related to an obesogenic environment of sociocultural, economic and marketing challenges to the control of body weight. Excess body fat is associated with nine cancer sites - oesophagus, colorectum, gall bladder, pancreas, postmenopausal breast, endometrium, ovary, kidney and prostate (advanced) - and 4-38% of these cancers (depending on site and gender) can be attributed to overweight/obesity status. Metabolic alterations which accompany excess body weight are accompanied by increased levels of inflammation, insulin, oestrogens and other hormonal factors. There are some indications that intentional weight loss is associated with reduced cancer incidence (notably in postmenopausal breast and endometrial cancers). Excess body weight is also a risk factor for several other diseases, including diabetes and heart disease, and is related to higher risk of premature death.In reviewing the current evidence related to excess body fat and cancer, the European Code against Cancer Nutrition Working Group has developed the following recommendation: 'Take action to be a healthy body weight'. (C) 2015 International Agency for Research on Cancer; Licensee ELSEVIER Ltd