A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD).
A controlled trial of the Litebook light-emitting diode (LED) light therapy device for treatment of Seasonal Affective Disorder (SAD).
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LiteBook发光二极管（LED）光疗法的对照试验，用于治疗季节性情感障碍（SAD）。
DOI：
10.1186/1471-244x-7-38
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发表时间：
2007-08-07
期刊：
影响因子：
4.4
通讯作者：
Lam, Raymond W.
中科院分区：
文献类型：
--
作者：
Desan, Paul H.;Weinstein, Andrea J.;Michalak, Erin E.;Tam, Edwin M.;Meesters, Ybe;Ruiter, Martine J.;Horn, Edward;Telner, John;Iskandar, Hani;Boivin, Diane B.;Lam, Raymond W.
最近的研究强调，人类的昼夜节律系统是不同的敏感短波长的光。使用其输出相对集中在短波长的高效发光二极管（LED）的光治疗设备可以实现对季节性情感障碍（SAD）的更方便有效的治疗。在一项随机、双盲、安慰剂对照、多中心试验中测试了LED光疗设备治疗SAD的疗效。年龄在18至65岁的SAD（DSM-IV季节性重度抑郁症）参与者在基线和随机化访视时观察，间隔1周，治疗后1周，2周，3周和4周。在每次访视时获得汉密尔顿抑郁量表评分（SIGH-SAD）。将在基线和随机化访视时SIGH-SAD为20或更大的参与者随机分配至活性或对照治疗：暴露于Litebook LED治疗装置（The Litebook Company Ltd.，阿尔伯塔，加拿大），其在20英寸的距离处提供1，350勒克斯的白色光（具有464 nm和564 nm的光谱发射峰值），或者提供到20英寸的距离处的未激活的负离子发生器，每天在醒来后和上午8点之前持续30分钟。在26名随机化的参与者中，23名完成了试验。平均组SIGH-SAD评分在随机化时无显著差异。试验结束时，在意向治疗分析和观察病例分析中，活性治疗组缓解（SIGH-SAD小于9）的受试者比例显著高于对照组（Fisher精确检验），SIGH-SAD评分（随机分组时的个体评分百分比）显著低于对照组（t检验）。SIGH-SAD评分的纵向重复测量ANOVA分析也表明时间和治疗的显著相互作用，显示Litebook优于安慰剂条件。这项初步研究的结果支持了Litebook光疗法是SAD有效治疗的假设。Clinicaltrials.gov：NCT00139997
Recent research has emphasized that the human circadian rhythm system is differentially sensitive to short wavelength light. Light treatment devices using efficient light-emitting diodes (LEDs) whose output is relatively concentrated in short wavelengths may enable a more convenient effective therapy for Seasonal Affective Disorder (SAD). The efficacy of a LED light therapy device in the treatment of SAD was tested in a randomized, double-blind, placebo-controlled, multi-center trial. Participants aged 18 to 65 with SAD (DSM-IV major depression with seasonal pattern) were seen at Baseline and Randomization visits separated by 1 week, and after 1, 2, 3 and 4 weeks of treatment. Hamilton Depression Rating Scale scores (SIGH-SAD) were obtained at each visit. Participants with SIGH-SAD of 20 or greater at Baseline and Randomization visits were randomized to active or control treatment: exposure to the Litebook LED treatment device (The Litebook Company Ltd., Alberta, Canada) which delivers 1,350 lux white light (with spectral emission peaks at 464 nm and 564 nm) at a distance of 20 inches or to an inactivated negative ion generator at a distance of 20 inches, for 30 minutes a day upon awakening and prior to 8 A.M. Of the 26 participants randomized, 23 completed the trial. Mean group SIGH-SAD scores did not differ significantly at randomization. At trial end, the proportions of participants in remission (SIGH-SAD less than 9) were significantly greater (Fisher's exact test), and SIGH-SAD scores, as percent individual score at randomization, were significantly lower (t-test), with active treatment than with control, both in an intent-to-treat analysis and an observed cases analysis. A longitudinal repeated measures ANOVA analysis of SIGH-SAD scores also indicated a significant interaction of time and treatment, showing superiority of the Litebook over the placebo condition. The results of this pilot study support the hypothesis that light therapy with the Litebook is an effective treatment for SAD. Clinicaltrials.gov: NCT00139997