Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.
Nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes inhibit alpha(4)beta(2) neuronal nicotinic acetylcholine receptors.
复制标题
非卤化麻醉烷烃和全卤化非固定烷烃抑制 α(4)β(2) 神经元烟碱乙酰胆碱受体。
DOI：
10.1097/00000539-200209000-00015
复制
发表时间：
2002
影响因子：
5.7
通讯作者：
Forman,StuartA
中科院分区：
文献类型：
--
作者：
Raines,DouglasE;Claycomb,RobertJ;Forman,StuartA
The nonhalogenated anesthetic alkanes, cyclopropane and butane, do not enhance γ-aminobutyric acid-elicited GABAergic currents, suggesting that these agents produce anesthesia via interactions with other molecular targets. Perhalogenated nonimmobilizing alkanes, such as 1, 2-dichlorohexafluorocyclobutane and 2, 3-dichlorooctafluorobutane, also fail to enhance GABAergic currents, but display specific behavioral effects that are distinct from those of structurally similar anesthetics. At concentrations predicted to be anesthetic, 1, 2-dichlorohexafluorocyclobutane and 2, 3-dichlorooctafluorobutane produce amnesia but fail to produce immobility. Neuronal nicotinic acetylcholine (nACh) receptors are sensitive to many anesthetics and are thought to have an important role in learning and memory. We postulated that neuronal nACh receptors might mediate the common amnestic action of nonhalogenated and perhalogenated alkanes. To test the hypothesis that neuronal nACh receptors have a role in mediating the behavioral effects of general anesthetics and nonimmobilizers, we quantified the inhibitory potencies of nonhalogenated anesthetic alkanes and perhalogenated nonimmobilizing alkanes on currents mediated by α 4 β 2 neuronal nACh receptors. Our studies reveal that anesthetics and nonimmobilizers significantly inhibit α 4 β 2 neuronal nACh receptors at concentrations that suppress learning and with potencies that correlate with their hydrophobicities. These results support the hypothesis that α 4 β 2 neuronal nACh receptors mediate the amnestic actions of alkanes but not their immobilizing actions.
