Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy
Drug addiction: targeting dynamic neuroimmune receptor interactions as a potential therapeutic strategy
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DOI：
10.1016/j.coph.2015.10.010
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发表时间：
2016-02-01
影响因子：
4
通讯作者：
Mustafa, Sanam
中科院分区：
文献类型：
--
作者：
Jacobsen, Jonathan Henry W.;Hutchinsont, Mark R.;Mustafa, Sanam
药物成瘾和依赖已被证明是难以治疗的精神疾病。神经作用药物，如阿坎酸和纳洛酮的疗效有限，突出了需要确定新的目标。最近的研究强调了神经免疫系统在药物成瘾的许多行为表现中的重要性。在这篇综述中，我们建议，我们欣赏复杂的表型，如药物成瘾和依赖，将有更大的理解，这些疾病是复杂的，相互关联的信号通路的结果，如果只是部分，在受体水平上确定。受体异聚化和受体镶嵌的想法将被引入解释神经免疫信号通路中涉及的受体和信号分子之间的串扰。
Drug addiction and dependence have proven to be difficult psychiatric disorders to treat. The limited efficacy of neuronally acting medications, such as acamprosate and naltrexone, highlights the need to identify novel targets. Recent research has underscored the importance of the neuroimmune system in many behavioural manifestations of drug addiction. In this review, we propose that our appreciation for complex phenotypes such as drug addiction and dependence will come with a greater understanding that these disorders are the result of intricate, interconnected signalling pathways that are, if only partially, determined at the receptor level. The idea of receptor heteromerisation and receptor mosaics will be introduced to explain cross talk between the receptors and signalling molecules implicated in neuroimmune signalling pathways.