Cutaneous immune responses mediated by dendritic cells and mast cells.
Cutaneous immune responses mediated by dendritic cells and mast cells.
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DOI：
10.1172/jci.insight.123947
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发表时间：
2019-01
期刊：
影响因子：
8
通讯作者：
T. Sumpter;S. Balmert;D. Kaplan
中科院分区：
文献类型：
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作者：
T. Sumpter;S. Balmert;D. Kaplan
在皮肤中，复杂的细胞网络维持屏障功能和免疫平衡。严格调控的多细胞级联反应是启动先天和获得性免疫反应所必需的。先天免疫细胞，特别是树突状细胞和肥大细胞，是这些网络的中心。早期的研究孤立地评估了这些细胞的功能，但最近的研究清楚地表明，皮肤DC(真皮DC和朗格汉斯细胞)与邻近细胞物理上相互作用，并接受来自周围细胞的激活信号，如肥大细胞。这些相互作用放大了免疫激活。在这篇综述中，我们讨论了皮肤DC群体和肥大细胞的已知功能，以及最近的研究，强调了它们在决定皮肤免疫反应的细胞网络中的作用。
In the skin, complex cellular networks maintain barrier function and immune homeostasis. Tightly regulated multicellular cascades are required to initiate innate and adaptive immune responses. Innate immune cells, particularly DCs and mast cells, are central to these networks. Early studies evaluated the function of these cells in isolation, but recent studies clearly demonstrate that cutaneous DCs (dermal DCs and Langerhans cells) physically interact with neighboring cells and are receptive to activation signals from surrounding cells, such as mast cells. These interactions amplify immune activation. In this review, we discuss the known functions of cutaneous DC populations and mast cells and recent studies highlighting their roles within cellular networks that determine cutaneous immune responses.