Hepatic and extrahepatic malignancies in primary sclerosing cholangitis
Hepatic and extrahepatic malignancies in primary sclerosing cholangitis
复制标题
DOI：
10.1016/s0168-8278(01)00288-4
复制
发表时间：
2002-03-01
影响因子：
25.7
通讯作者：
Broomé, U
中科院分区：
文献类型：
--
作者：
Bergquist, A;Ekbom, A;Broomé, U
背景/目标：为了评估瑞典原发性硬化性胆管炎（PSC）患者与一般Swedish population.Methods相比，在一个大的队列中肝和肝外恶性肿瘤的风险：该研究队列包括604例PSC患者在1970年和1998年之间确定。通过与瑞典癌症和死亡登记处的联系提供随访。恶性肿瘤的累积发病率和标准发病率比计算与瑞典人口的发病率，考虑到：性别，年龄和日历年作为comparinggroup.Results：随访的中位时间为5.7年（范围0-27.8）。79%伴有炎症性肠病。44%的死亡原因是癌症。肝癌发生率为13.3%（81/604）。所有肝胆恶性肿瘤中有37%（30/81）在PSC诊断后不到1年内被诊断。肝胆恶性肿瘤的风险增加了161倍，结直肠癌10倍，胰腺癌14倍，与一般population.Conclusions相比：在这个国家为基础的研究，包括最大的队列PSC患者以往任何时候都提出，胆管癌的频率是13%。在PSC诊断后第一年后，肝胆癌的风险是恒定的，每年的发病率为1.5%。与瑞典普通人群相比，胰腺癌的风险增加了14倍。这些结果提示PSC患者发生胰腺癌的风险增加。C 2002欧洲肝脏研究协会。由Elsevier Science B. V.出版，版权所有。
Background/Aims: To assess the risk of hepatic and extrahepatic malignancies in a large cohort of Swedish primary sclerosing cholangitis (PSC) patients compared with that of the general Swedish population.Methods: The study cohort comprised 604 PSC patients identified between 1970 and 1998. Follow-up was provided through linkages to the Swedish Cancer and Death registries. Cumulative incidence of malignancies and standard incidence ratio were calculated with the incidence rates in the Swedish population, taking into account: sex, age and calendar year as comparison group.Results: Median time of follow-up was 5.7 years (range 0-27.8). Seventy-nine percent had concomitant inflammatory bowel disease. The cause of death was cancer in 44%. The frequency of hepatobillary malignancies was 13.3% (81/604). Thirty-seven percent (30/81) of all hepatobiliary malignancies were diagnosed less than 1 year after the diagnosis of PSC. The risk for hepatobiliary malignancy was increased 161 times, for colorectal carcinoma 10 times and for pancreatic carcinoma 14 times, compared with that of the general population.Conclusions: In this national-based study including the largest cohort of PSC patients ever presented, the frequency of cholangiocarcinoma is 13%. The risk of hepatobiliary carcinoma is constant after the first year after PSC diagnosis with an incidence rate of 1.5% per year. The risk of pancreatic carcinoma is increased 14 times compared with the general Swedish population. These results are suggestive of an increased risk of pancreatic carcinoma in patients with PSC. C 2002 European Association for the Study of the Liver. Published by Elsevier Science B.V. All rights reserved.