SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion
SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion
复制标题
DOI：
10.1007/s10404-017-1941-4
复制
发表时间：
2017-06-01
影响因子：
2.8
通讯作者：
Ingber, Donald E.
中科院分区：
文献类型：
--
作者：
Domansky, Karel;Sliz, Josiah D.;Ingber, Donald E.
大多数用于细胞培养的微流体装置，包括器官芯片（器官芯片），都是使用聚二甲基硅氧烷（PDMS）聚合物制造的，因为它是柔性的，光学透明的，易于成型。然而，PDMS对于大批量生产具有重大挑战，并且其吸收小的疏水化合物的倾向限制了其作为用于药物评价研究的装置中的材料的有用性。在这里，我们证明了一个子集的光学透明的，弹性体，苯乙烯嵌段共聚物的基础上苯乙烯-乙烯-丁烯-苯乙烯表现出减少的吸收的小疏水分子和药物化合物相比，PDMS和它们可以被制造成微流体装置的精细功能和灵活性所需的器官芯片使用大规模生产技术的注塑成型和挤出。
The majority of microfluidic devices used for cell culture, including Organ-on-a-Chips (Organ Chips), are fabricated using polydimethylsiloxane (PDMS) polymer because it is flexible, optically clear, and easy to mold. However, PDMS possesses significant challenges for high volume manufacturing and its tendency to absorb small hydrophobic compounds limits its usefulness as a material in devices used for drug evaluation studies. Here, we demonstrate that a subset of optically clear, elastomeric, styrenic block copolymers based on styrene-ethylene-butylene-styrene exhibit reduced absorption of small hydrophobic molecules and drug compounds compared to PDMS and that they can be fabricated into microfluidic devices with fine features and the flexibility required for Organ Chips using mass production techniques of injection molding and extrusion.