Matrix resin effects on selected physicochemical properties of amorphous calcium phosphate composites
Matrix resin effects on selected physicochemical properties of amorphous calcium phosphate composites
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DOI：
10.1177/0883911505050082
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发表时间：
2005-01-01
影响因子：
1.7
通讯作者：
Skrtic, D
中科院分区：
文献类型：
--
作者：
Antonucci, JM;Skrtic, D
无定形磷酸钙（ACP）填充的生物活性复合材料在牙科应用中显示出良好的前景。本研究的重点是聚合物-填料粘结，以改善这些复合材料的物理化学性能。光活化树脂由乙氧基化双酚A二甲基丙烯酸酯（EBPADMA）、三甘醇二甲基丙烯酸酯（TEGDMA）、甲基丙烯酸2-羟乙酯（HEMA）和甲基丙烯酰氧基乙基邻苯二甲酸酯（MEP）以四种不同的EBPADMA/TEGDMA质量比（1.0、0.67、0.5和0.25）和恒定的HEMA/MEP质量比2.0配制。采用氧化锆-ACP（质量分数40%）制备复合材料。复合材料和共聚物的双轴弯曲强度（BFS），乙烯基转化率（DC）和吸水性（WS）进行了评价。还评估了复合材料的矿物离子释放和聚合收缩（PS）。独立的树脂组合物，平均BFS为130 +/- 24 MPa的干和水浸泡的共聚物，但为70 - 11 MPa的干复合材料和47 +/- 7 MPa的湿复合材料。所有复合材料的平均DC为84 +/- 5%，并且显示出对树脂组合物的依赖性很小。共聚物和复合材料的WS均为3.2 +/-0.6%，其中树脂组成仅在一种配方EBPADMA/TEGDMA 0.67中是一个因素。总体离子释放量显著高于再矿化所需的理论最小值。然而，钙离子水平低于先前观察到的类似的复合材料的基础上没有MEP的树脂。这很可能是由于它们与MEP的羧酸基团结合。由于共聚物的DC和复合材料的PS都随着树脂中的EBPADMA/TEGDMA比率的降低而增加，因此提高树脂中的EBPADMA/TEGDMA比率似乎是改善复合材料的PS而不会不利地影响BFS、WS和/或离子释放的明显方式，同时仅略微降低DC。
Amorphous calcium phosphate (ACP)-filled bioactive composites show promise in a number of dental applications. This study focused on polymer-filler bonding as a way to improve physicochemical properties of these composites. Photoactivated resins were formulated from ethoxylated bisphenol A dimethacrylate (EBPADMA), triethylene glycol dimethacrylate (TEGDMA), 2-hydroxyethyl methacrylate (HEMA) and methacryloxyethyl phthalate (MEP) with four different EBPADMA/TEGDMA mass ratios (1.0, 0.67, 0.5 and 0.25) and a constant HEMA/MEP mass ratio of 2.0. Composites were prepared with the zirconia-ACP (mass fraction 40%). Composites and copolymers were evaluated for their biaxial flexure strength (BFS), degree of vinyl conversion (DC) and water sorption (WS). Composites were also assessed for mineral ion release and polymerization shrinkage (PS). Independent of resin composition, the average BFS was 130 +/- 24 MPa for both the dry and aqueous-immersed copolymers, but was 70 11 MPa for the dry composites and 47 +/- 7 MPa for the wet composites. The average DC of all of the composites was 84 +/- 5% and showed little dependence on resin composition. The WS of both copolymers and composites was 3.2 +/- 0.6% with resin composition being a factor in only one formulation EBPADMA/TEGDMA 0.67. Overall ion release was significantly above the theoretical minimum necessary for remineralization. However, Ca ion levels were lower than that observed previously for similar composites based on resins without MEP. This is most likely due to their binding with the carboxylic acid groups of MEP. Since the DC of the copolymers and the PS of the composites both increased with decreasing EBPADMA/TEGDMA ratio in the resin, elevating the EBPADMA/TEGDMA ratio in the resin seems to be an obvious way to improve the PS of composites without adversely affecting the BFS, WS and/or ion release, while only marginally reducing the DC.