Biometric, optical and physical changes in the isolated human crystalline lens with age in relation to presbyopia
Biometric, optical and physical changes in the isolated human crystalline lens with age in relation to presbyopia
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DOI：
10.1016/s0042-6989(98)00283-1
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发表时间：
1999-06-01
期刊：
影响因子：
1.8
通讯作者：
Campbell, MCW
中科院分区：
文献类型：
--
作者：
Glasser, A;Campbell, MCW
比较了19对年龄从5岁到96岁的离体人眼库晶状体的生物计量、光学和物理性能。使用扫描激光装置测量透镜焦距和球差，通过数字化透镜轮廓测量透镜厚度和透镜表面曲率，并利用这些数据计算每个透镜的等效折射率。来自每个供体的第二个透镜被用来通过向透镜提供压力来测量对物理变形的抵抗力。然后将晶状体囊从每个晶状体上取出，并重复每次测量，以确定晶状体囊在确定这些光学和物理特性方面所起的作用。描述了透镜焦距、透镜表面曲率和对物理变形的抵抗力随年龄的变化。孤立晶状体的焦距与前表面和后表面曲率均呈显著的线性相关。未发现隔离晶状体的等效折射率随年龄的变化。尽管人类晶状体的拆封引起的焦距变化与我们已经证明的人类晶状体机械伸展到不适应状态时的焦距变化相似，但这种影响是由于晶状体曲率的非系统性变化造成的。这些研究强化了这样的结论，即晶状体硬化必须被视为老花眼发展的一个重要因素，人类晶状体的年龄变化不仅限于老花眼特征的调节能力的丧失，而且晶状体的光学和物理特性随着年龄的增长以一种复杂的方式发生实质性变化。(C)1999爱思唯尔科学有限公司。保留所有权利。
The biometric, optical and physical properties of 19 pairs of isolated human eye-bank lenses ranging in age from 5 to 96 years were compared. Lens focal length and spherical aberration were measured using a scanning laser apparatus, lens thickness and the lens surface curvatures were measured by digitizing the lens profiles and equivalent refractive indices were calculated for each lens using this data. The second lens from each donor was used to measure resistance to physical deformation by providing a compressive force to the lens. The lens capsule was then removed from each lens and each measurement was repeated to ascertain what role the capsule plays in determining these optical and physical characteristics. Age dependent changes in lens focal length, lens surface curvatures and lens resistance to physical deformation are described. Isolated lens focal length was found to be significantly linearly correlated with both the anterior and posterior surface curvatures. No age dependent change in equivalent refractive index of the isolated lens was found. Although decapsulating human lenses causes similar changes in focal length to that which we have shown to occur when human lenses are mechanically stretched into an unaccommodated state, the effects are due to nonsystematic changes in lens curvatures. These studies reinforce the conclusion that lens hardening must be considered as an important factor in the development of presbyopia, that age changes in the human lens are not limited to the loss of accommodation that characterizes presbyopia but that the lens optical and physical properties change substantially with age in a complex manner. (C) 1999 Elsevier Science Ltd. All rights reserved.