Calcium Deficiency Reduces Circulating Levels of FGF23
Calcium Deficiency Reduces Circulating Levels of FGF23
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DOI：
10.1681/asn.2011101006
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发表时间：
2012-07-01
影响因子：
13.6
通讯作者：
Almaden, Yolanda
中科院分区：
文献类型：
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作者：
Rodriguez-Ortiz, Maria E.;Lopez, Ignacio;Almaden, Yolanda
成纤维细胞生长因子（FGF）23抑制骨化三醇的产生，这可能会加剧钙缺乏或低钙血症，除非钙本身在这种情况下调节FGF 23。在肾功能正常的Wistar大鼠中，喂食低钙和维生素D的饮食，导致的低钙血症与低FGF 23相关，尽管甲状旁腺激素（PTH）和高骨化三醇水平。FGF 23与血钙呈正相关，与PTH呈负相关。除了在低钙血症的大鼠中，尽管PTH水平高，但在这种饮食中添加高膳食磷增加了FGF 23。在甲状旁腺切除大鼠中，膳食钙增加10天，血清钙增加，FGF 23相关增加，骨化三醇减少，磷无变化。同样在甲状旁腺切除大鼠中，在给予葡萄糖酸钙后6小时，FGF 23显著增加。总之，这些结果表明低钙血症降低了FGF 23的循环浓度。FGF23的这种减少可能是为了避免随后的骨化三醇减少，这可能会加剧低钙血症。
Fibroblast growth factor (FGF) 23 inhibits calcitriol production, which could exacerbate calcium deficiency or hypocalcemia unless calcium itself modulates FGF23 in this setting. In Wistar rats with normal renal function fed a diet low in both calcium and vitamin D, the resulting hypocalcemia was associated with low FGF23 despite high parathyroid hormone (PTH) and high calcitriol levels. FGF23 correlated positively with calcium and negatively with PTH. Addition of high dietary phosphorus to this diet increased FGF23 except in rats with hypocalcemia despite high PTH levels. In parathyroidectomized rats, an increase in dietary calcium for 10 days increased serum calcium, with an associated increase in FGF23, decrease in calcitriol, and no change in phosphorus. Also in parathyroidectomized rats, FGF23 increased significantly 6 hours after administration of calcium gluconate. Taken together, these results suggest that hypocalcemia reduces the circulating concentrations of FGF23. This decrease in FGF23 could be a response to avoid a subsequent reduction in calcitriol, which could exacerbate hypocalcemia.