Kinetically stable complexes in water: The role of hydration and hydrophobicity
Kinetically stable complexes in water: The role of hydration and hydrophobicity
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DOI：
10.1021/ja038823m
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发表时间：
2004-03-10
影响因子：
15
通讯作者：
Rebek, J
中科院分区：
文献类型：
--
作者：
Biros, SM;Ullrich, EC;Rebek, J
本文描述了一种在水中形成动力学和热力学稳定的主客体络合物的分子受体的合成和表征。这种以空洞为基础的宿主由一个预先组织的芳香口袋组成，其边缘装饰着四个带负电荷的羧酸基。用H-1核磁共振和等温滴定量热法表征了在十二烷基硫酸钠胶束存在下，所合成的络合物在pH、缓冲剂特性和盐浓度变化时的行为。
We describe here the synthesis and characterization of a molecular receptor that forms kinetically and thermodynamically stable host-guest complexes in water. This cavitand-based host is composed of a preorganized aromatic pocket whose rim is decorated with four negatively charged carboxylate groups. H-1 NMR and isothermal titration calorimetry have been used to characterize the behavior of the resulting complexes in response to changes in pH, buffer identity, and salt concentration and in the presence of sodium dodecyl sulfate micelles.