Preparation and characterization of biomedical highly porous Ti-Nb alloy
Preparation and characterization of biomedical highly porous Ti-Nb alloy
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生物医用高孔Ti-Nb合金的制备及表征
DOI：
10.1007/s10856-016-5685-6
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发表时间：
2016
期刊：
影响因子：
--
通讯作者：
Zhou Kechao
中科院分区：
文献类型：
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作者：
Ruan Jianming;Yang Hailin;Weng Xiaojun;Miao Jinglei;Zhou Kechao
采用海绵浸渍和烧结相结合的方法制备了多孔ti - 25wt %Nb合金，并对其抗压强度和生物相容性进行了评价。该合金的孔径为300 ~ 600 μm，孔隙率为71±1.5%，其中开孔体积分数为94±1.3%。测试结果表明，该合金的压缩杨氏模量为2.23±0.5 GPa，强度为98.4±4.5 MPa，力学性能与人骨相似。扫描电镜（SEM）观察表明，孔隙连通良好，形成三维（3D）网状开孔结构。此外，多孔结构中未检测到明显的杂质。实验还证实了兔骨间充质干细胞（MSCs）能够在多孔ti - 25wt %Nb合金中粘附和增殖。多孔合金与电池之间的相互作用是由于多孔结构具有较高的表面。该材料具有良好的力学性能和生物相容性，在组织工程中具有广阔的应用前景。
The compressive strength and the biocompatibility were assessed for the porous Ti–25 wt%Nb alloy fabricated by the combination of the sponge impregnation technique and sintering technique. The alloy provided pore sizes of 300–600 μm, porosity levels of 71 ± 1.5 %, in which the volume fraction of open pores was 94 ± 1.3 %. The measurements also showed that the alloy had the compressive Young’s modulus of 2.23 ± 0.5 GPa and the strength of 98.4 ± 4.5 MPa, indicating that the mechanical properties of the alloy are similar to those of human bone. The scanning electron microscopy (SEM) observations revealed that the pores were well connected to form three-dimension (3D) network open cell structure. Moreover, no obvious impurities were detected in the porous structure. The experiments also confirmed that rabbit bone mesebchymal stem cells (MSCs) could adhere and proliferate in the porous Ti–25 wt%Nb alloy. The interactions between the porous alloy and the cells are attributed to the porous structure with relatively higher surface. The suitable mechanical and biocompatible properties confirmed that this material has a promising potential in the application for tissue engineering.