A simulation-based study on water radiolysis species for 1H+, 4He2+, and 12C6+ ion beams with multiple ionization using Geant4-DNA
A simulation-based study on water radiolysis species for 1H+, 4He2+, and 12C6+ ion beams with multiple ionization using Geant4-DNA
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DOI：
10.1063/5.0054665
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发表时间：
2021-06-28
影响因子：
3.2
通讯作者：
Ishikawa, Masayori
中科院分区：
文献类型：
--
作者：
Baba, Kentaro;Kusumoto, Tamon;Ishikawa, Masayori
蒙特卡罗径迹结构模拟是估算水辐解产物杀伤细胞损伤的有效方法。为了研究H1（+）、He 4（2+）和C 12（6+）离子束下多重电离对水辐解产物形成的影响，采用基于Geant 4-DNA的Monte Carlo模拟方法进行了模拟. H2 O2的G值随着线性能量转移的增加而单调增加，最高可达200 eV/nm。在200 eV/nm以上，H2 O2的G值开始下降，但仅当考虑多重电离的影响时。这一趋势与实验结果吻合较好。此外，我们成功地再现了HO 2中心点+ O-2（中心点-）的G值的实验结果。本文还讨论了多重电离在H_2O_2、HO_2中心点、O_2-（中心点-）和O_2-产生中的作用。
Monte Carlo track structure simulation is a powerful method for estimating damage induced by water radiolysis products for cell killing. To investigate the influence of multiple ionization for the formation of water radiolysis products under H-1(+), He-4(2+), and C-12(6+) ion beams, a Monte Carlo simulation based on Geant4-DNA was carried out. The G-value of H2O2 increased monotonically with increasing linear energy transfer up to 200 eV/nm. Above 200 eV/nm, the G-value of H2O2 began dropping, but only when the influence of multiple ionization was considered. This trend is in good agreement with the experimental results. Furthermore, we successfully reproduce the experimental results of G-values of HO2 center dot + O-2(center dot-). The role of the multiple ionization in the production of H2O2, HO2 center dot, O-2(center dot-), and O-2 is also discussed.