The accuracy of preoperative core biopsy in determining histologic grade, hormone receptors, and human epidermal growth factor receptor 2 status in invasive breast cancer
The accuracy of preoperative core biopsy in determining histologic grade, hormone receptors, and human epidermal growth factor receptor 2 status in invasive breast cancer
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DOI：
10.1016/j.amjsurg.2007.11.024
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发表时间：
2009-02-01
影响因子：
3
通讯作者：
Kim, Sung-Won
中科院分区：
文献类型：
--
作者：
Park, So Yeon;Kim, Ku Sang;Kim, Sung-Won
背景：在术前全身治疗前，正确确定核心活检标本的组织学类型和生物标志物是很重要的。本研究的目的是通过比较分析核心活检和手术标本中的组织学分级（HG）、激素受体和人表皮生长因子受体2 （HER-2）状态，来确定术前核心活检的准确性。方法：我们确定了104例浸润性导管癌患者，他们在我们的机构接受了核心活检和最终手术。病理学家对核心活检和手术标本的组织学类型、HG、雌激素受体（ER）、孕激素受体（PR）和HER-2状态进行了检测。结果：104例患者的平均年龄为50±9.9岁，平均核心活检次数为5.1.9次。组织学类型、HG、ER、PR和HER-2状态的符合率分别为100%、80.8%、99%、97.1%和86.5%。结论：如果使用得当，核心活检可预测乳腺癌术前组织学类型、HG、ER、PR和HER-2状态。(C) 2009爱思唯尔公司版权所有。
BACKGROUND: Proper determination of histologic type and biomarkers in a core biopsy specimen is important before preoperative systemic therapy. The purpose of this study was to determine the accuracy of preoperative core biopsy through comparative analysis of histologic grade (HG), hormone receptors, and human epidermal growth factor receptor 2 (HER-2) status in both the core biopsy and surgical specimens.METHODS: We identified 104 patients with invasive ductal cancer who underwent core biopsy and definitive surgery in our institution. The histologic type, HG, estrogen receptor (ER), progesterone receptor (PR), and HER-2 status were determined in both the core biopsy and surgical specimens by one pathologist.RESULTS: The mean age of the 104 patients was 50 +/- 9.9 years and the mean number of core biopsies was 5.1.9. The concordance rates for histologic type, HG, ER, PR, and HER-2 status were 100%, 80.8%, 99%, 97.1%, and 86.5%, respectively.CONCLUSIONS: Core biopsy can predict histologic type, HG, ER, PR and HER-2 status preoperatively in breast cancer when used properly. (C) 2009 Elsevier Inc. All rights reserved.