Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice
Sleep deprivation impairs the extinction of cocaine-induced environmental conditioning in mice
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DOI：
10.1016/j.pbb.2014.05.001
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发表时间：
2014-09-01
影响因子：
3.6
通讯作者：
Frussa-Filho, R.
中科院分区：
文献类型：
--
作者：
Berro, L. F.;Hollais, A. W.;Frussa-Filho, R.
反复的精神兴奋剂治疗引起的药物环境条件作用的持续被认为在成瘾循环中起关键作用。此外，睡眠障碍是成瘾性障碍患者的一个共同特征。睡眠剥夺与精神兴奋剂有着相似的神经生物学效应。因此，我们研究了睡眠剥夺是否会损害先前在药物作用和环境线索之间建立的条件反射的消失。四组雄性成年小鼠进行了行为致敏试验，将药物（可卡因15 mg/kg， i.p）或生理盐水与环境（露天装置）配对。在对照组（家养笼子维持）或睡眠剥夺（温和处理6小时）条件下评估条件运动的消退。在可卡因致敏动物中，睡眠剥夺既推迟了先前药物环境条件反射促进的条件运动的开始，又损害了条件运动的完全消失。可卡因对照组需要5次无药暴露在野外装置中才能完全消除条件运动，而可卡因预处理组在每次消失前经历睡眠剥夺，在消失的第5天仍然与各自的对照组有显著差异。睡眠状况可能会影响药物作用和环境因素之间的长期联系的消失，这可能代表了临床相关现象的新结果。(C) 2014爱思唯尔公司版权所有。
Persistence of a drug-environment conditioning induced by repeated psychostimulant treatment is thought to play a key role in the addictive cycle. In addition, sleep disorders are a common feature in patients with addictive disorders. Sleep deprivation shares similar neurobiological effects with psychostimulants. Therefore, we investigated whether sleep deprivation would impair the extinction of previously established conditioning between the drug effect and the environmental cues. Four cohorts of male adult mice underwent a behavioral sensitization procedure pairing drug (cocaine at 15 mg/kg, i.p.) or saline with environment (open-field apparatus). The extinction of conditioned locomotion was evaluated after control (home-cage maintained) or sleep deprivation (gentle handling method for 6 h) conditions. Sleep deprivation both postponed the initiation and impaired the completeness of extinction of the conditioned locomotion promoted by previous drug-environment conditioning in cocaine-sensitized animals. While the cocaine control group required 5 free-drug sessions of exposure to the open-field apparatus to complete extinction of conditioned locomotion, the cocaine pre-treated group that experienced sleep deprivation before each extinction session still significantly differed from its respective control group on Day 5 of extinction. The possibility that the sleep condition can influence the extinction of a long-lasting association between drug effects and environmental cues can represent new outcomes for clinically relevant phenomena. (C) 2014 Elsevier Inc. All rights reserved.