Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up
Mortality and cancer incidence of aircraft maintenance workers exposed to trichloroethylene and other organic solvents and chemicals: extended follow up
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DOI：
10.1136/oem.55.3.161
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发表时间：
1998-03-01
影响因子：
4.9
通讯作者：
Lubin, J
中科院分区：
文献类型：
--
作者：
Blair, A;Hartge, P;Lubin, J
Objectives-To extend the follow up of a cohort of 14 457 aircraft maintenance workers to the end of 1990 to evaluate cancer risk from potential exposure to trichloroethylene and other chemicals. Methods-The cohort included civilian employed for at least one year between 1952 and 1956，whose 5727 had died by 31 December 1990.分析比较了队列的死亡率与一般人口的犹他州和暴露工人的死亡率和癌症发病率与那些未暴露于化学品，同时调整年龄，性别，和日历time.Results-In合并随访期间（1952年至1990年），死亡率从所有原因和所有癌症接近预期（标准化死亡率比（SMR）97和96，分别）。缺血性心脏病（SMR 108）、哮喘（SMR 160）和骨癌（SMR 227）的患病率显著过高，而脑血管病（SMR 88）、事故（SMR 70）和中枢神经系统癌症的患病率显著不足。（相对危险度（RR）2.0），食管癌（RR 5.6）、结肠癌（RR 1.4）、原发性肝癌（RR 1.7）、乳腺癌（RR 1.8）、宫颈癌（RR 1.8）、肾癌（RR 1.6）和骨癌（RR 2.1）。这些癌症都没有表现出一个反应梯度和RR暴露于其他化学品的工人，但不是三氯乙烯的10个有大的RR暴露于三氯乙烯的工人。暴露于三氯乙烯以外的溶剂的工人有轻微增加的死亡率哮喘，非霍奇金淋巴瘤，多发性骨髓瘤，和breastcancer. Conclusion，这些研究结果强烈支持因果三氯乙烯，因为协会是不显着的，没有明确的剂量相关，男性和女性之间的不一致。由于实验调查和其他流行病学研究的结果，溶剂以外的三氯乙烯提供了一些生物相容性，这些化学品和非霍奇金淋巴瘤，多发性骨髓瘤，乳腺癌之间的联系，这里发现值得进一步关注。虽然这种长期的随访不能排除接触溶剂与某些疾病之间的联系，但似乎很明显，这些工人的癌症死亡率或癌症发病率并没有大幅增加。
Objectives-To extend the follow up of a cohort of 14 457 aircraft maintenance workers to the end of 1990 to evaluate cancer risks from potential exposure to trichloroethylene and other chemicals.Methods-The cohort comprised civilians employed for at least one year between 1952 and 1956, of whom 5727 had died by 31 December 1990. Analyses compared the mortality of the cohort with the general population of Utah and the mortality and cancer incidence of exposed workers with those unexposed to chemicals, while adjusting for age, sex, and calendar time.Results-In the combined follow up period (1952-90), mortality from all causes and all cancer was close to expected (standardised mortality ratios (SMRs) 97 and 96, respectively). Significant excesses occurred for ischaemic heart disease (SMR 108), asthma (SMR 160), and cancer of the bone (SMR 227), whereas significant deficits occurred for cerebrovascular disease (SMR 88), accidents (SMR 70), and cancer of the central nervous system Workers exposed to trichloshowed non-significant excesses for non-Hodgkin's lymphoma (relative risk (RR) 2.0), and cancers of the oesophagus (RR 5.6), colon (RR 1.4), primary liver (RR 1.7), breast (RR 1.8), cervix (RR 1.8), kidney (RR 1.6), and bone (RR 2.1). None of these cancers showed an exposure-response gradient and RRs among workers exposed to other chemicals but not trichlorethylene of ten had RRs as large as workers exposed to trichloroethylene. Workers exposed to solvents other than trichloroethylene had slightly increased mortality from asthma, non-Hodgkin's lymphoma, multiple myeloma, and breast cancer.Conclusion-These findings strongly support a causal trichloroethylene because the associations were not significant, not clearly dose-related, and inconsistent between men and women. Because findings from experimental investigations and other epidemiological studies on solvents other than trichloroethylene provide some biological plausibility, the suggested links between these chemicals and nonHodgkin's lymphoma, multiple myeloma, and breast cancer found here deserve further attention. Although this extended follow up cannot rule out a connection between exposures to solvents and some diseases, it seems clear that these workers have not experienced a major increase in cancer mortality or cancer incidence.