Molecular phylogeny of modern coxsackievirus A16
Molecular phylogeny of modern coxsackievirus A16
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DOI：
10.1007/s00705-006-0934-5
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发表时间：
2007-06-01
影响因子：
2.7
通讯作者：
Cardosa, M. J.
中科院分区：
文献类型：
--
作者：
Perera, D.;Yusof, M. A.;Cardosa, M. J.
对最近 52 个 CVA16 菌株的 VP1 和 VP4 核苷酸序列进行的系统发育分析表明，有两个不同的 CVA16 基因组 A 和 B，其中原型菌株是基因组 A 的唯一成员。原型菌株 CVA16 G-10 的 VP1 和 VP4 与其他菌株相比，分别显示出 27.7-30.2% 和 19.9-25.2% 的核苷酸差异。 CVA16 菌株，在基因组 B 中形成两个独立的谱系，VP1 和 VP4 的核苷酸变异分别小于 13.4% 和小于 16.3%。 2000 年之前流行的谱系 1 菌株后来被谱系 2 菌株取代。
A phylogenetic analysis of VP1 and VP4 nucleotide sequences of 52 recent CVA16 strains demonstrated two distinct CVA16 genogroups, A and B, with the prototype strain being the only member of genogroup A. CVA16 G-10, the prototype strain, showed a nucleotide difference of 27.7-30.2% and 19.9-25.2% in VP1 and VP4, respectively, in relation to other CVA16 strains, which formed two separate lineages in genogroup B with nucleotide variation of less than 13.4% and less than 16.3% in VP1 and VP4, respectively. Lineage 1 strains circulating before 2000 were later displaced by lineage 2 strains.