Plasmonic nanobubbles as tunable cellular probes for cancer theranostics.
Plasmonic nanobubbles as tunable cellular probes for cancer theranostics.
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DOI：
10.3390/cancers3010802
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发表时间：
2011-02-23
期刊：
影响因子：
5.2
通讯作者：
Lapotko D
中科院分区：
文献类型：
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作者：
Lapotko D
本文综述了一种新型的细胞探针，等离子体纳米气泡（PNB），它具有动态可调和成像，诊断，交付，治疗，并最终，治疗诊断学的多种功能。最近引入了治疗诊断学的概念，以便将临床上重要的治疗阶段，即诊断，治疗和治疗指导，统一为一个单一，快速和高度准确的程序。细胞水平的治疗诊断学将对癌症和其他疾病的早期治疗产生深远的影响。开发PNB以支持细胞水平治疗诊断学，作为新一代按需可调细胞探针。PNB是一种瞬态蒸汽纳米气泡，它是在纳秒内用短激光脉冲在过热的等离子体纳米颗粒周围产生的。在短期内，我们预计PNB技术将迅速适用于临床医学，它提供的单细胞分辨率对于诊断早期或残留疾病以及消除癌细胞至关重要，同时保持健康细胞完好无损。本文综述了等离子体纳米气泡的作用机制及其在生物医学中的应用，重点是癌细胞治疗诊断学。
This review is focused on a novel cellular probe, the plasmonic nanobubble (PNB), which has the dynamically tunable and multiple functions of imaging, diagnosis, delivery, therapy and, ultimately, theranostics. The concept of theranostics was recently introduced in order to unite the clinically important stages of treatment, namely diagnosis, therapy and therapy guidance, into one single, rapid and highly accurate procedure. Cell level theranostics will have far-reaching implications for the treatment of cancer and other diseases at their earliest stages. PNBs were developed to support cell level theranostics as a new generation of on-demand tunable cellular probes. A PNB is a transient vapor nanobubble that is generated within nanoseconds around an overheated plasmonic nanoparticle with a short laser pulse. In the short term, we expect that PNB technology will be rapidly adaptable to clinical medicine, where the single cell resolution it provides will be critical for diagnosing incipient or residual disease and eliminating cancer cells, while leaving healthy cells intact. This review discusses mechanisms of plasmonic nanobubbles and their biomedical applications with the focus on cancer cell theranostics.