Identification of (2-aminopropyl)benzofuran (APB) phenyl ring positional isomers in internet purchased products.
Identification of (2-aminopropyl)benzofuran (APB) phenyl ring positional isomers in internet purchased products.
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网上购买产品中（2-氨基丙基）苯并呋喃（APB）苯环位置异构体的鉴定。
DOI：
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发表时间：
2013
影响因子：
2.9
通讯作者：
P. Kavanagh
中科院分区：
文献类型：
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作者：
A. Stańczuk;N. Morris;E. A. Gardner;P. Kavanagh
5-(2-氨基丙基)苯并呋喃 (5-APB) 是一种“研究化学品”，由英国当局于 2010 年首次向欧洲毒品和毒瘾监测中心 (EMCDDA) 报告，据传闻，它会产生刺激和致诱作用。最近，2011 年，匈牙利当局鉴定出 6-(2-氨基丙基)苯并呋喃 (6-APB)。为了确认网上购买的产品中的位置异构体身份，合成了 4-5-6- 和 7-APB，发现可以通过气相色谱（作为七氟丁酰胺衍生物）和液相色谱进行分离。对从“研究化学品”在线供应商购买的产品进行分析后发现，其中存在 5- 或 6-APB。这些发现通过液相色谱-质谱法和（1）H核磁共振波谱法得到进一步证实。在含有 6-APB 的产品中，还发现了 4 位异构体，这可能是在制造过程中出现的。
5-(2-Aminopropyl)benzofuran (5-APB), a 'research chemical' that was first reported by UK authorities to the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) in 2010, is anecdotally reported to produce a combination of stimulant and entactogenic effects. More recently, in 2011, 6-(2-aminopropyl)benzofuran (6-APB) was identified by Hungarian authorities. To confirm positional isomer identity in Internet purchased products, 4- 5- 6- and 7-APBs were synthesized and found to be separable by gas chromatography (as heptafluorobutyramide derivatives) and liquid chromatography. The analyses of products purchased from online vendors of 'research chemicals' identified the presence of 5- or 6-APBs. These findings were further confirmed by liquid chromatography-mass spectrometry and (1) H nuclear magnetic resonance spectroscopy. In products containing 6-APB, the 4- positional isomer was also identified and this may have arisen during the manufacturing process.