Environmental Health Perspectives
Environmental Health Perspectives
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DOI：
10.1289/ehp.110-1240809
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发表时间：
2002-04
影响因子：
10.4
通讯作者：
T. Goehl
中科院分区：
文献类型：
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作者：
T. Goehl
背景：二恶英、呋喃和多氯联苯（PCBs），二恶英类和非二恶英类，与青春期的改变有关。目的：我们研究了这些化合物（及其毒性当量（TEQs））的青春期血清水平与青春期开始和成熟的俄罗斯男孩在8-9岁，并前瞻性地跟踪到17-18岁。方法：在入学时，473名男孩血清二恶英样化合物和多氯联苯测定。在基线访视时和每年直至17-18岁，由医生进行青春期分期[生殖器（G）、阴阜（P）和睾丸体积（TV）]。315例受试者在17-18岁时完成了随访访视。青春期开始定义为TV>3 mL、G2或P2。性成熟定义为TV≥20 mL、G5或P5。多变量区间删失模型被用来评估脂质标准化浓度与青春期时间的关系。结果如下：二恶英类化合物、毒性当量和非二恶英类多氯联苯总和的中位数（四分位数范围）分别为362皮克/克脂质（279-495）、21.1皮克毒性当量/克脂质（14.4-33.2）和250纳克/克脂质（164-395）。在校正模型中，与最低TEQ四分位数相比，最高TEQ四分位数与青春期开始较晚（月; 95% CI）[TV 11.6（3.8，19.4）; G2 10.1（1.4，18.8）]和性成熟[TV 11.6（5.7，17.6）; G5 9.7（3.1，16.2）]相关。然而，最高的非二恶英样多氯联苯的四分位数与最低的四分位数相比，当通过TEQs共同调整时，与青春期开始较早相关[TV-8
Background: Dioxins, furans, and polychlorinated biphenyls (PCBs), dioxin-like and nondioxin-like, have been linked to alterations in puberty. Objectives: We examined the association of peripubertal serum levels of these compounds (and their toxic equivalents (TEQs)) with pubertal onset and maturity among Russian boys enrolled at ages 8–9 years and followed prospectively through ages 17-18 years. Methods: At enrollment, 473 boys had serum dioxin-like compounds and PCBs measured. At the baseline visit and annually until age 17-18 years, a physician performed pubertal staging [Genitalia (G), Pubarche (P), and testicular volume (TV)]. 315 subjects completed the follow-up visit at 17-18 years of age. Pubertal onset was defined as TV>3 mL, G2, or P2. Sexual maturity was defined as TV≥20 mL, G5, or P5. Multivariable interval-censored models were used to evaluate associations of lipid-standardized concentrations with pubertal timing. Results: Medians (interquartile ranges) of the sum of dioxin-like compounds, TEQs, and nondioxin-like-PCBs were 362 pg/g lipid (279-495), 21.1 pg TEQ/g lipid (14.4-33.2), and 250 ng/g lipid (164-395), respectively. In adjusted models, the highest compared to lowest TEQ quartile was associated with later pubertal onset (months; 95% CI) [TV 11.6 (3.8, 19.4); G2 10.1 (1.4, 18.8)] and sexual maturity [TV 11.6 (5.7, 17.6); G5 9.7 (3.1, 16.2)]. However, the highest compared to the lowest quartile of nondioxin-like-PCBs, when co-adjusted by TEQs, was associated with earlier pubertal onset [TV -8