Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma.
Cytokeratin alteration in oral leukoplakia and oral squamous cell carcinoma.
复制标题
口腔白斑和口腔鳞状细胞癌中细胞角蛋白的改变。
DOI：
10.3892/or.18.3.639
复制
发表时间：
2007
期刊：
影响因子：
4.2
通讯作者：
H. Buerger
中科院分区：
文献类型：
--
作者：
T. Fillies;Mirco Jogschies;J. Kleinheinz;B. Brandt;U. Joos;H. Buerger
中间丝参与细胞迁移和细胞内信号转导途径。在多种器官中，不同中间丝的表达进一步与恶性转化的不同步骤相关。本研究旨在探讨细胞角蛋白（Ck）在口腔白斑和口腔鳞状细胞癌（OSCC）中的表达模式。应用组织芯片技术检测192例口腔鳞癌、117例无异型增生口腔白斑（OL）和23例口腔白斑伴异型增生（OLD）组织中Ck 5-6、Ck 8/18、Ck 1、Ck 10、Ck 14、Ck 19的表达。采用卡方检验对临床特征与细胞角蛋白表达的相关性进行统计学分析。Ck 8/18、Ck 19和Ck 1在所有白斑中的表达率分别为3.1%（Ck 8/18）、12.5%（Ck 19）、75.4%（Ck 1），在OL中的表达率分别为1.0%（Ck 8/18）、9.4%（Ck 19）、76.8%（Ck 1），13.0%（Ck 8/18）、27.3%（Ck 19）、OLD中Ck 1阳性率为68.4%，与异型增生程度（Ck 8/18 p<0.01; Ck 19 p<0.01; Ck 1 p<0.01）和浸润性生长特征的获得显著相关。在浸润性鳞状细胞癌中观察到最高频率。Ck 8/18和Ck 19在口腔癌转化灶中的表达可作为口腔癌发生的早期特征。然而，Ck 8/18和Ck 19在浸润性癌中以更高频率的异常表达表征了典型的腺细胞角蛋白的表达作为鳞状细胞癌中的一般进展标志物。这些结果可以解释为第一提示，口腔白斑与表达CK 8/18或19独立的异型增生，应完全切除，因为它们可能表明增加的进展潜力。
Intermediate filaments are involved in cell migration and intracellular signal transduction pathways. In a variety of organs, the expression of distinct intermediary filaments are further associated with distinct steps of malignant transformation. In this study, we seeked to define the cytokeratin (Ck) expression pattern in oral leukoplakia and oral squamous cell carcinoma (OSCC). One hundred and ninety-two patients with OSCC, 117 patients with oral leukoplakia without dysplasia (OL) and 23 with oral leukoplakia with dysplasia (squamous intraepithelial neoplasia) (OLD) of the oral cavity were investigated for the immunohistochemical expression of Ck 5-6, Ck 8/18, Ck 1 Ck 10, Ck 14, Ck 19 using the tissue microarray technique. Correlations between clinical features and the expression of cytokeratins were evaluated statistically by chi2 tests. The expression of Ck 8/18, Ck 19 and Ck 1 was seen in 3.1% (Ck 8/18), 12.5% (Ck 19), 75.4% (Ck 1) of all leukoplakias, 1.0% (Ck 8/18), 9.4% (Ck 19), 76.8% (Ck 1) in OL, 13.0% (Ck 8/18), 27.3% (Ck 19), 68.4% (Ck 1) in OLD and was significantly associated with the degree of dysplasia (Ck 8/18 p<0.01; Ck 19 p<0.01; Ck 1 p<0.01) and the acquisition of invasive growth properties. The highest frequencies were observed in invasive squamous cell carcinomas. The expression of Ck 8/18 and Ck 19 in transformed oral lesions can be regarded as an early feature in the pathogenesis of invasive OSCC. However, the aberrant expression of Ck 8/18 and Ck 19 in an even higher frequency in invasive carcinomas characterizes the expression of typical glandular cytokeratins as a general progression marker in squamous cell carcinomas. These results can be interpreted as first hints that oral leukoplakias with an expression of Ck 8/18 or 19 independent of dysplasia, should be resected totally since they might indicate an increased progression potential.
DOI：
--
发表时间：
1996
期刊：
The American journal of pathology
影响因子：
--
作者：
Yi Wen Chu;E. Seftor;Lewis H. Romer;M. J. Hendrix
通讯作者：
Yi Wen Chu;E. Seftor;Lewis H. Romer;M. J. Hendrix