Experimental strategies for increasing the catalyst turnover number in a continuous Heck coupling reaction
Experimental strategies for increasing the catalyst turnover number in a continuous Heck coupling reaction
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DOI：
10.1016/j.jcat.2013.06.020
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发表时间：
2013-10-01
影响因子：
7.3
通讯作者：
Livingston, Andrew G.
中科院分区：
文献类型：
--
作者：
Peeva, Ludmila;Burgal, Joao da Silva;Livingston, Andrew G.
本工作提出了一个连续的Heck偶联反应结合有机溶剂纳滤（OSN）分离的催化剂在原位，使用聚合物膜在高温（80 ℃）和高浓度的碱（>0.9 mol L-1）。研究了两种反应器配置：连续单搅拌釜反应器/膜分离器（m-CSTR）和活塞流反应器（PFR）后m-CSTR（PFR-m-CSTR）。研究发现，PFR-m-CSTR组合配置是最有前途的，可实现98%以上的转化率和接近20，000的高催化剂周转量（TON）。此外，产品流的低污染（类似于27 mg Pd/kg产品）使得该工艺配置对于制药工业具有吸引力。(C)2013 Elsevier Inc. All rights reserved.
This work presents a continuous Heck coupling reaction combined with organic solvent nanofiltration (OSN) separation of the catalyst in situ, using polymeric membranes at high temperature (80 C) and high concentration of base (>0.9 mol L-1). Two reactor configurations are investigated: a continuous single stirred tank reactor/membrane separator (m-CSTR) and a plug flow reactor (PFR) followed by m-CSTR (PFR-m-CSTR). The combined PFR-m-CSTR configuration was found to be the most promising, achieving conversions above 98% and high catalyst turnover numbers (TONs) of similar to 20,000. In addition, low contamination of the product stream (similar to 27 mg Pd per kg of product) makes this process configuration attractive for the pharmaceutical industry. (C) 2013 Elsevier Inc. All rights reserved.