INDUCTION OF TRANSPLANTATION TOLERANCE IN GUINEA PIGS BY SPLEEN ALLOGRAFTS: I. OPERATIVE TECHNIQUES AND CLINICAL RESULTS
INDUCTION OF TRANSPLANTATION TOLERANCE IN GUINEA PIGS BY SPLEEN ALLOGRAFTS: I. OPERATIVE TECHNIQUES AND CLINICAL RESULTS
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同种异体脾脏诱导豚鼠移植耐受：一、手术技术和临床结果
DOI：
10.1097/00007890-198201000-00010
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发表时间：
1982
期刊：
影响因子：
6.2
通讯作者：
E. Shevach
中科院分区：
文献类型：
--
作者：
H. Bitter;E. Shevach
在品系 2 和品系 13 的近交豚鼠中进行了 410 例异位脾移植，其主要组织相容性复合体仅在 I 区域不同，并且快速排斥相互皮肤同种异体移植物。从品系 13 到品系 2 的同种异体脾移植物在宿主的整个一生中都存活，而从品系 2 到品系 13 的同种异体脾移植物在 3 周内被排斥。不排斥脾脏移植的动物对供体品系皮肤同种异体移植物具有特别耐受性。品系 13 脾移植物的品系 2 受体因移植物抗宿主病而具有令人惊讶的高死亡率，该死亡率在移植后 6 周达到峰值。
Four hundred and ten heterotopic spleen transplants were performed in inbred guinea pigs of strains 2 and 13 whose major histocompatibility complex differs only in the I region and which rapidly reject reciprocal skin allografts. Spleen allografts from strain 13 to strain 2 survived throughout the lifetime of the hosts, whereas spleen allografts from strain 2 to strain 13 were rejected within 3 weeks. Animals not rejecting their spleen transplants were specifically tolerant of donor strain skin allografts. Strain 2 recipients of strain 13 spleen grafts had a surprisingly high mortality from graft-versue host disease which peaked at 6 weeks after transplantation.