Signal Transduction in Early Heart Development (I): Cardiogenic Induction and Heart Tube Formation
Signal Transduction in Early Heart Development (I): Cardiogenic Induction and Heart Tube Formation
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DOI：
10.3181/00379727-232-2320852
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发表时间：
2007-07
影响因子：
3.2
通讯作者：
M. Wagner;M. Siddiqui
中科院分区：
文献类型：
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作者：
M. Wagner;M. Siddiqui
心脏的发育始于胚胎中胚层的心源性细胞的诱导，随后这些细胞合并成线性心管。随后的心管成环使未发育的心房和心室对齐，以便进一步发育成四腔心脏。这些形态学事件的基础是细胞和组织之间的复杂信号程序，该程序协调它们参与心脏发育。这些信号包括骨形态发生蛋白、成纤维细胞生长因子、Wnt、Hedgehog和信号分子的转化生长因子-β家族的成员。我们在这里回顾这些信号分子的各种特性和它们的信号转导途径，希望提供一个更大的赞赏的分子事件驱动心脏发育。
Heart development begins with the induction of cardiogenic cells from the embryonic mesoderm, followed by the coalescing of these cells into a linear heart tube. Subsequent looping of the heart tube brings the rudimentary atria and ventricles into alignment for further development into the four-chambered heart. Underlying these morphologic events is a complex program of signaling between cells and tissues that orchestrates their participation in heart development. Among these signals are bone morphogenetic proteins, fibroblast growth factors, Wnts, Hedgehog, and members of the transforming growth factor-β family of signaling molecules. We review here the various properties of these signaling molecules and their signal transduction pathways in hopes of providing a greater appreciation of the molecular events driving heart development.