Group III metabotropic glutamate receptors and D1-like and D2-like dopamine receptors interact in the rat nucleus accumbens to influence locomotor activity
Group III metabotropic glutamate receptors and D1-like and D2-like dopamine receptors interact in the rat nucleus accumbens to influence locomotor activity
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DOI：
10.1046/j.1460-9568.2002.01919.x
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发表时间：
2002-03-01
影响因子：
3.4
通讯作者：
Abraini, JH
中科院分区：
文献类型：
--
作者：
David, HN;Abraini, JH
代谢性谷氨酸(MGlu)受体和多巴胺(DA)神经传递之间功能相互作用的证据现已明确。在本研究中，我们研究了伏隔核(NAcc)中第三组mGlu受体与D-1和D-2样受体之间的相互作用。向NAcc内注入选择性的III型mGlu受体激动剂AP4可引起NAcc运动活动的增加，这种作用可被III型mGlu受体拮抗剂MPPG阻断。此外，预先给予AP4进一步阻断了D-1样受体激动剂SKF 38393引起的运动活动增加，但增强了D-2样受体激动剂奎比罗或SKF 38393和奎比罗联合应用所引起的运动反应。MPPG可逆转AP4对D-1和/或D-2样受体激活引起的运动反应的影响。这些结果证实谷氨酸传递可能通过mGlu受体控制DA依赖的运动功能，并进一步表明III型mGlu受体反对D-1样受体激活所产生的行为反应，而有利于D-2样受体激活所产生的行为反应。
Evidence for functional interactions between metabotropic glutamate (mGlu) receptors and dopamine (DA) neurotransmission is now clearly established. In the present study, we investigated interactions between group III mGlu receptors and D-1- and D-2-like receptors in the nucleus accumbens (NAcc). Administration, into the NAcc, of the selective group III mGlu receptor agonist, AP4, resulted in an increase in locomotor activity, which was blocked by pretreatment with the group III mGlu receptor antagonist, MPPG. In addition, pretreatment with AP4 further blocked the increase in motor activity induced by the D-1-like receptor agonist, SKF 38393, but potentiated the locomotor responses induced by either the D-2-like receptor agonist, quinpirole, or coinfusion of SKF 38393 and quinpirole. MPPG reversed the effects of AP4 on the motor responses induced by D-1-like and/or D-2-like receptor activation. These results confirm that glutamate transmission may control DA-dependent locomotor function through mGlu receptors and further indicate that group III mGlu receptors oppose the behavioural response produced by D-1-like receptor activation and favour those produced by D-2-like receptor activation.