How superoxide radical damages the cell
How superoxide radical damages the cell
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DOI：
10.1007/bf01289410
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发表时间：
2001-01-01
期刊：
影响因子：
2.9
通讯作者：
Benov, L
中科院分区：
文献类型：
--
作者：
Benov, L
超氧化物被认为反应性差，细胞损伤归因于HO。通过Haber-Weiss反应生成。O-2（-）的函数。在这个反应中只将Fe3+还原为Fe2+。然而，在体内，超氧化物不能胜过细胞还原剂，如谷胱甘肽、NADPH和抗坏血酸，这使得观察到的O-2（-）毒性相当令人费解。很少有人注意到，尽管超氧化物的化学反应性很差，但它可能能够直接与特定的细胞内目标相互作用；甚至哈伯-韦斯反应也可能是这种直接相互作用的结果。本文总结了支持这种机制概念的最新数据。
Superoxide is considered to be poorly reactive, and cell damage has been attributed to HO. generated via the Haber-Weiss reaction. The function of O-2(-). in this reaction is only to reduce Fe3+ to Fe2+. In vivo, however, superoxide could not out-compete cellular reductants such as glutathione, NADPH, and ascorbate, which makes the observed O-2(-) toxicity rather puzzling. Little attention has been paid to the idea that, irrespective of its poor chemical reactivity, superoxide might be capable of interacting directly with specific intracellular targets; and that even the Haber-Weiss reaction might be a consequence of such direct interactions. This paper summarizes latest data that support the concept of such a mechanism.