Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258.
Bacteriophage Treatment Rescues Mice Infected with Multidrug-Resistant Klebsiella pneumoniae ST258.
复制标题
噬菌体治疗抢救感染多重耐药肺炎克雷伯氏菌ST258的小鼠。
DOI：
10.1128/mbio.00034-21
复制
发表时间：
2021-02-23
期刊：
影响因子：
6.4
通讯作者：
DeLeo FR
中科院分区：
文献类型：
--
作者：
Hesse S;Malachowa N;Porter AR;Freedman B;Kobayashi SD;Gardner DJ;Scott DP;Adhya S;DeLeo FR
Severe infections caused by multidrug-resistant Klebsiella pneumoniae sequence type 258 (ST258) highlight the need for new therapeutics with activity against this pathogen. Bacteriophage (phage) therapy is an alternative treatment approach for multidrug-resistant bacterial infections that has shown efficacy in experimental animal models and promise in clinical case reports. In this study, we assessed microbiologic, histopathologic, and survival outcomes following systemic administration of phage in ST258-infected mice. We found that prompt treatment with two phages, either individually or in combination, rescued mice with K. pneumoniae ST258 bacteremia. Among the three treatment groups, mice that received combination phage therapy demonstrated the greatest increase in survival and the lowest frequency of phage resistance among bacteria recovered from mouse blood and tissue. Our findings support the utility of phage therapy as an approach for refractory ST258 infections and underscore the potential of this treatment modality to be enhanced through strategic phage selection.
