New sequence variants associated with bone mineral density
New sequence variants associated with bone mineral density
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DOI：
10.1038/ng.284
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发表时间：
2009-01-01
期刊：
影响因子：
30.8
通讯作者：
Stefansson, Kari
中科院分区：
文献类型：
--
作者：
Styrkarsdottir, Unnur;Halldorsson, Bjarni V.;Stefansson, Kari
在一项对6,865名冰岛人进行的全基因组范围的骨密度关联研究和对8,510名欧洲血统受试者的跟踪调查中，我们确定了四个新的全基因组显著基因座。它们分别是位于17q21的SOST基因、位于14q32的Mark3基因、位于12q13的SP7基因和位于18q21的TNFRSF11A(RANK)基因。此外，C17orf53、LRP4、ADAM19和IBSP基因中的非同义SNPs可能与骨密度相关。
In an extended genome-wide association study of bone mineral density among 6,865 Icelanders and a follow-up in 8,510 subjects of European descent, we identified four new genome-wide significant loci. These are near the SOST gene at 17q21, the MARK3 gene at 14q32, the SP7 gene at 12q13 and the TNFRSF11A (RANK) gene at 18q21. Furthermore, nonsynonymous SNPs in the C17orf53, LRP4, ADAM19 and IBSP genes were suggestively associated with bone density.