MEASUREMENT OF CORONARY SINUS BLOOD FLOW BY CONTINUOUS THERMODILUTION IN MAN
MEASUREMENT OF CORONARY SINUS BLOOD FLOW BY CONTINUOUS THERMODILUTION IN MAN
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DOI：
10.1161/01.cir.44.2.181
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发表时间：
1971-01-01
期刊：
影响因子：
37.8
通讯作者：
SWAN, HJC
中科院分区：
文献类型：
--
作者：
GANZ, W;TAMURA, K;SWAN, HJC
本文介绍了一种连续热稀释法测量人冠状窦血流量的技术。对于单次测定，在室温下以35 ml/min的恒定速率注射5%葡萄糖约20秒。14例冠状动脉正常者的平均冠状窦血流量为122 ± 25 ml/min（范围：83 ~ 159 ml/min）。每100 g左心室血流量为82 ± 16 ml/min，在氧化亚氮法和符合计数法的范围内。35例经冠状动脉造影证实的冠心病患者的平均血流量相似（128 ± 20 ml/min，范围92 ~ 167 ml/min），用特制导管同时测量冠状静脉窦和心大静脉的血流量。8例正常人心大静脉血流量为68 ± 11 ml/min（51 ~ 78 ml/min），占冠状静脉血流量的65 ± 10%。该方法允许在几分钟内连续测量流量，并首次测量心肌灌注的快速变化。
A technique was developed for measurement of blood flow in the coronary sinus in man by continuous thermodilution. For single determinations, 5% dextrose at room temperature is injected at a constant rate of 35 ml/min for a period of about 20 sec. In 14 subjects with normal coronary arteries the mean coronary sinus blood flow was 122 ± 25 ml/min (range, 83 to 159 ml/min). The blood flow computed per 100 g of left ventricle was 82 ± 16 ml/min, which is in the range of values obtained by nitrous oxide and coincidence counting methods. In 35 patients with arteriographically confirmed coronary artery disease the mean flow was similar (128 ± 20 ml/min; range, 92 to 167 ml/min).A special catheter was used for simultaneous measurement of blood flow in the coronary sinus and great cardiac vein. In eight normal subjects the mean great cardiac vein flow was 68 ± 11 ml/min (range, 51 to 78 ml/min) or 65 ± 10% of the coronary sinus blood flow. The method allowed continuous measurement of flow over a period of several minutes and, for the first time, measurement of rapid changes in myocardial perfusion.