Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin
Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin, and thrombomodulin
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DOI：
10.1161/01.atv.17.3.505
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发表时间：
1997-03-01
影响因子：
8.7
通讯作者：
Bode, C
中科院分区：
文献类型：
--
作者：
Peter, K;Nawroth, P;Bode, C
动脉粥样硬化的二级预防，特别是在症状发作之前，似乎是可取的，并可能与血清标志物检测动脉粥样硬化。循环中脱落形式的粘附分子可能是这样的，因为它们的表达在动脉粥样硬化斑块中上调。在52例外周动脉血管疾病患者中（方丹IIa级，7例; IIb级，29例; III级，16例），动脉粥样硬化的程度是根据大部分动脉系统的血管造影片进行评价的。动脉粥样硬化病变面积由以下计算的节段的血管壁不规则性的百分比确定：主动脉（肾动脉远端）、髂总动脉、髂外动脉、股总动脉、旋股外侧动脉和腘动脉。可表现出动脉粥样硬化变化的最大表面积为250 cm 2。血清VCAM-1浓度与动脉粥样硬化程度呈正相关（r= 0.8，P
Secondary prevention of atherosclerosis, especially before the onset of symptoms, appears desirable and could be possible with a serum marker detecting atherosclerosis. Circulating, shedded forms of adhesion molecules may serve as such because their expression is upregulated in atherosclerotic plaques. In 52 patients with peripheral arterial vascular disease (Fontaine class Ila, 7 patients; class IIb, 29 patients; and class III, 16 patients), the extent of atherosclerosis was evaluated on the basis of angiograms of a large portion of the arterial system. The area diseased by atherosclerosis was determined by the percentage of vessel wall irregularities of the following calculated segments: aorta (distal from the kidney arteries), common iliac artery, external iliac artery, common femoral artery, lateral circumflex femoral artery, and popliteal artery. The maximal surface area that could exhibit atherosclerotic changes was 250 cm(2). The serum concentration of circulating vascular cell adhesion molecule-1 (VCAM-1) correlated with the extent of atherosclerosis (r=.8, P