Functional Genomics
Functional Genomics
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DOI：
10.1007/978-3-319-98758-3_2
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发表时间：
2018-01-01
期刊：
影响因子：
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通讯作者：
Loke，Kok-Keong
中科院分区：
文献类型：
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作者：
Goh，Hoe-Han;Ng，Chyan Leong;Loke，Kok-Keong
功能基因组学包括分子生物学和生物信息学的不同学科，以理解定义生物体生理学的遗传元件的蓝图，调控和表达。后基因组时代的测序数据洪流要求计算机科学家和数学家参与创建算法、分析软件和数据库，以存储、管理和分析生物大数据。在本章中，我们讨论了系统生物学背景下的功能基因组学概念，并提供了其在人类遗传疾病研究，分子作物改良和抗生素发现宏基因组学中的应用实例。还介绍了转录组学工作流程和实验考虑的概述。最后，我们提出了一个内部的案例研究的转录组学分析的芳香草药植物，以了解挥发性有机化合物的生物合成的启发的效果。
Functional genomics encompasses diverse disciplines in molecular biology and bioinformatics to comprehend the blueprint, regulation, and expression of genetic elements that define the physiology of an organism. The deluge of sequencing data in the postgenomics era has demanded the involvement of computer scientists and mathematicians to create algorithms, analytical software, and databases for the storage, curation, and analysis of biological big data. In this chapter, we discuss on the concept of functional genomics in the context of systems biology and provide examples of its application in human genetic disease studies, molecular crop improvement, and metagenomics for antibiotic discovery. An overview of transcriptomics workflow and experimental considerations is also introduced. Lastly, we present an in-house case study of transcriptomics analysis of an aromatic herbal plant to understand the effect of elicitation on the biosynthesis of volatile organic compounds.