Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project.
Very old adults with better memory function have higher low-density lipoprotein cholesterol levels and lower triglyceride to high-density lipoprotein cholesterol ratios: KOCOA Project.
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DOI：
10.3233/jad-121138
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
Dodge HH
中科院分区：
文献类型：
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作者：
Katsumata Y;Todoriki H;Higashiuesato Y;Yasura S;Ohya Y;Willcox DC;Dodge HH
我们对 80 岁及无痴呆症（临床痴呆评分≤ 0.5）、功能独立且居住在社区的老年人中哪些血脂谱与更好的认知功能相关进行了横断面研究。我们的队列由来自日本冲绳的一项前瞻性队列研究“最佳认知老化的关键 (KOCOA) 项目”的 193 名参与者组成。控制混杂因素后，较高的低密度脂蛋白胆固醇水平和较低的甘油三酯/高密度脂蛋白胆固醇（TG/HDL-C）比率与较高的记忆表现得分相关。需要进一步的研究来阐明 LDL-C 水平、TG/HDL-C 比率和健康认知衰老之间的关联。
We examined cross-sectionally which lipid profiles are associated with better cognitive function among those aged 80 and older-free of dementia (Clinical Dementia Rating ≤ 0.5), functionally independent and community-dwelling. Our cohort consisted of 193 participants from the “Keys to Optimal Cognitive Aging (KOCOA) Project”, a prospective cohort study in Okinawa, Japan. Higher low-density lipoprotein cholesterol levels and lower triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) ratios were associated with higher scores in memory performance after controlling for confounders. Further research is required to clarify the associations among LDL-C levels, TG/HDL-C ratios, and healthy cognitive aging.