Excess hospital admissions for pneumonia, chronic obstructive pulmonary disease, and heart failure during influenza seasons in Hong Kong
Excess hospital admissions for pneumonia, chronic obstructive pulmonary disease, and heart failure during influenza seasons in Hong Kong
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DOI：
10.1002/jmv.20135
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发表时间：
2004-08-01
影响因子：
12.7
通讯作者：
Peiris, JSM
中科院分区：
文献类型：
--
作者：
Yap, FHY;Ho, PL;Peiris, JSM
人们普遍认为，中国南方是出现大流行性流感病毒的假设流感中心。然而，与西方国家相比，流感在世界这一地区被认为是一种相对不重要的感染。香港位于假设的震中之内，是区内的前哨。在一项回顾性研究中，1998年至2001年期间，通过一个模型估计了年龄≥ 65岁的患者因肺炎、慢性阻塞性肺疾病（COPD）、心力衰竭和哮喘在地区医院的流感相关过度住院，该模型考虑了其他呼吸道病毒感染、季节因素、时间趋势、以及天气和污染指数。在回归模型中，流感活动是影响肺炎、COPD和心力衰竭住院率的独立显著因素，但不是影响哮喘住院率的独立显著因素。流感活动导致的肺炎、COPD和心力衰竭住院率的变化分别为38.9%、7.5%和45.6%。1998年、1999年、2000年和2001年，三种诊断合并的流感相关过度住院率分别为每10，000名年龄大于或等于65岁的人群中58.5、20.0、29.2和13.4人。总括而言，香港65岁或以上的长者因流感活动而入院的次数显著增加，与西方国家报告的数据相若。研究结果支持在该地区更广泛地应用年度流感疫苗接种。(C)2004 Wiley-Liss，Inc.
It is widely held that Southern China is a hypothetical influenza epicentre for the emergence of pandemic influenza viruses. However, influenza is perceived as a relatively unimportant infection in this part of the world compared with western countries. Hong Kong is situated within the hypothetical epicentre and serves as a sentinel post for the region. In a retrospective study, the influenza-associated excess hospitalisations in a regional hospital for pneumonia, chronic obstructive pulmonary disease (COPD), heart failure, and asthma in persons aged greater than or equal to 65 years from 1998 to 2001 were each estimated by a model taking into consideration the confounding effect of other respiratory viral infections, seasonal factors, time trends, and weather and pollution indices. In the regression models, influenza activity is an independent significant factor affecting admission rates for pneumonia, COPD, and heart failure but not that for asthma. The variations in hospital admissions for pneumonia, COPD, and heart failure explained by influenza activity were 38.9, 7.5, and 45.6%, respectively. The adjusted rates of excess influenza-associated hospital admissions for the three diagnoses combined amounted to 58.5, 20.0, 29.2, and 13.4 per 10,000 populations aged greater than or equal to 65 years in 1998, 1999, 2000, and 2001, respectively. In conclusion, influenza activity is associated significant excess hospital admissions among elderly aged 65 or above in Hong Kong, comparable to the data reported in Western countries. The findings support a wider application of annual influenza vaccination in this region. (C) 2004 Wiley-Liss, Inc.