Platelet Activity in Habitual Smokers
Platelet Activity in Habitual Smokers
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习惯吸烟者的血小板活性
DOI：
10.1055/s-0038-1646495
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发表时间：
1991
影响因子：
6.7
通讯作者：
P. Elwood
中科院分区：
文献类型：
--
作者：
A. Beswick;S. Renaud;J. Yarnell;P. Elwood
Foo，Roshidah和Aimy在一项针对习惯性吸烟者的仔细对照研究中报告了全血血小板聚集减少（1）。他们认为，他们的研究结果排除了血小板活性增强在吸烟受试者缺血性心脏病中的作用。Caerphilly心脏病研究的横截面结果也显示，戒烟超过一小时的习惯性吸烟者的血小板对全血中二磷酸腺苷的敏感性明显较低（2）（表1）。然而，对腺苷二磷酸的敏感性被发现在那些受试者中增加谁曾吸烟前不久venesection。这一观察结果与血小板对吸烟的急性反应的实验研究一致（3，4，5）。吸烟后血小板活性立即增强，随后“反弹”减少的潜在机制尚不清楚。可能
Foo, Roshidah and Aimy report reduced whole blood platelet aggregation in a carefully controlled study of habitual smokers (1). They suggest that their results preclude a role for enhanced platelet activity in ischaemic heart disease in subjects who smoke. Cross sectional results from the Caerphilly Heart Disease Study also show a markedly lower sensitivity of platelets to adenosine diphosphate in whole blood among habitual smokers who had abstained for over an hour (2) (Table 1). However, the sensitivity to adenosine diphosphate was found to be increased in those subjects who had smoked cigarettes shortly before venesection. This observation is consistent with experimental studies of the acute responses of platelets to smoking (3, 4, 5). The underlying mechanism of this immediate potentiation of platelet activity after smoking followed by a "rebound" reduction is not clear. It may be