Forward conditioning with wheel running causes place aversion in rats
Forward conditioning with wheel running causes place aversion in rats
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DOI:
10.1016/j.beproc.2008.04.006
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发表时间:
2008-09-01
影响因子:
1.3
通讯作者:
Nakajima, Sadahiko
中科院分区:
文献类型:
--
作者:
Masaki, Takahisa;Nakajima, Sadahiko
Backward pairings of a distinctive chamber as a conditioned stimulus and wheel running as an unconditioned stimulus (i.e., running-then-chamber) can produce a conditioned place preference in rats. The present study explored whether a forward conditioning procedure with these stimuli (i.e., chamber-thenrunning) would yield place preference or aversion. Confinement ofa rat in one oftwo distinctive chambers was followed by a 20- or 60-min running opportunity, but confinement in the other was not. After four repetitions of this treatment (i.e., differential conditioning), a choice preference test was given in which the rat had free access to both chambers. This choice test showed that the rats given 60-min running opportunities spent less time in the running-paired chamber than in the unpaired chamber. Namely, a 60-min running opportunity after confinement in a distinctive chamber caused conditioned aversion to that chamber after four paired trials. This result was discussed with regard to the opponent-process theory of motivation. (c) 2008 Elsevier BY. All rights reserved