Precise chronology of differentiation of developing human primary dentition
Precise chronology of differentiation of developing human primary dentition
复制标题
人类乳牙列发育分化的精确年表
DOI：
10.1007/s00418-013-1149-y
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发表时间：
2014-02-01
影响因子：
2.3
通讯作者：
Zhang, Yanding
中科院分区：
文献类型：
--
作者：
Hu, Xuefeng;Xu, Shan;Zhang, Yanding
虽然人类乳牙发育阶段与胚胎年龄的相关性已经被很好地记录下来，但关于乳牙分化时间的现有信息很大程度上是基于对初始矿化的观察，并且差异很大。在这项研究中，我们旨在记录发育中的人类乳牙列的精确分化时间。我们系统地研究了牙源性分化标志物的表达和矿化组织在每个发育中的上颌牙齿和下颌牙齿中的形成，这些组织来自具有明确胚龄的人类胚胎。我们发现，尽管所有乳牙都同时开始发育，但牙源性分化始于孕15周的上颌门牙和孕16周的下颌切牙，然后依次是尖牙、第一乳前磨牙和第二乳前磨牙，间隔一周。尽管下颌乳门牙的萌出早于上颌门牙，但人类乳牙列的远中近中顺序分化与牙齿萌出的顺序大体一致。我们的研究结果为人类乳牙发育过程中牙源性分化提供了准确的年代学依据，可为今后人类牙齿发育的研究提供参考。
While correlation of developmental stage with embryonic age of the human primary dentition has been well documented, the available information regarding the differentiation timing of the primary teeth was largely based on the observation of initial mineralization and varies significantly. In this study, we aimed to document precise differentiation timing of the developing human primary dentition. We systematically examined the expression of odontogenic differentiation markers along with the formation of mineralized tissue in each developing maxillary and mandibular teeth from human embryos with well-defined embryonic age. We show that, despite that all primary teeth initiate development at the same time, odontogenic differentiation begins in the maxillary incisors at the 15th week and in the mandibular incisors at the 16th week of gestation, followed by the canine, the first primary premolar, and the second primary premolar at a week interval sequentially. Despite that the mandibular primary incisors erupt earlier than the maxillary incisors, this distal to proximal sequential differentiation of the human primary dentition coincides in general with the sequence of tooth eruption. Our results provide an accurate chronology of odontogenic differentiation of the developing human primary dentition, which could be used as reference for future studies of human tooth development.