Corneal Sensitivity and Slit Scanning In Vivo Confocal Microscopy of the Subbasal Nerve Plexus of the Normal Central and Peripheral Human Cornea
Corneal Sensitivity and Slit Scanning In Vivo Confocal Microscopy of the Subbasal Nerve Plexus of the Normal Central and Peripheral Human Cornea
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DOI：
10.1097/ico.0b013e318193e0e3
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发表时间：
2009-08-01
期刊：
影响因子：
2.8
通讯作者：
McGhee, Charles N. J.
中科院分区：
文献类型：
--
作者：
Patel, Dipika V.;Tavakoli, Mitra;McGhee, Charles N. J.
目的：测定角膜5个部位的基底神经密度和屈光度，并探讨其与角膜敏感度的关系。方法：60例60只眼随机分为3个年龄组，第1组：50岁。结果：平均基底神经密度和平均角膜敏感度中央最大(分别为14,731±6056µm/mm(2)和0.38±0.21毫巴)，鼻中周缘最低(分别为7850±4947µm/mm(2)和0.49±0.25毫巴)。基底下神经的平均迂回系数在颞中周缘最大(27.3+/-6.4)，在中上周缘最低(19.3+/-14.1)。各年龄组间基底下神经平均密度差异无统计学意义。而角膜知觉(P=0.001)和基底下神经弯曲(P=0.004)在不同年龄组之间差异有统计学意义。基底下神经密度仅与颞侧角膜皮质敏感度阈值、内侧和鼻侧角膜基底下神经曲度显著相关。结论：本研究定量分析了活体人角膜神经结构和神经功能的一个方面。基底神经密度与角膜知觉无明显相关性。这项研究为正常活体人角膜中央和中周位置提供了有用的基线数据。
Purpose: To determine the subbasal nerve density and tortluosity at 5 corneal locations and to investigate whether these microstructural observations correlate with corneal sensitivity.Method: Sixty eyes of 60 normal human Subjects were recruited into 1 of 3 age groups, group 1 : aged 50 years. All eyes were examined Using slit-lamp biomicroscopy, noncontact conical esthesiometry, and slit scanning in vivo confocal microscopy.Results: The mean subbasal nerve density and the mean corneal sensitivity were greatest centrally (14,731 +/- 6056 mu m/mm(2) and 0.38 +/- 0.21 millibars, respectively) and lowest in the nasal mid periphery (7850 +/- 4947 mu m/mm(2) and 0.49 +/- 0.25 millibars, respectively). The mean subbasal nerve tortuosity coefficient was greatest in the temporal mid periphery (27.3 +/- 6.4) and lowest in the superior mid periphery (19.3 +/- 14. 1). There was no significant difference in mean total subbasal nerve density between age groups. However, corneal sensation (P = 0.001) and subbasal nerve tortuosity (P = 0.004) demonstrated significant differences between age groups. Subbasal nerve density only showed significant correlations with cortical sensitivity threshold in the temporal cornea and with subbasal nerve tortuosity in the interior and nasal cornea. However, these correlations were weak.Conclusions: This study quantitatively analyzes living human corneal nerve structure and an aspect of nerve function. There is no strong correlation between subbasal nerve density and corneal sensation. This study provides useful baseline data for the normal living human cornea at central and mid-peripheral locations.