Morphological alterations in hippocampus after long-term alcohol consumption in mice.
Morphological alterations in hippocampus after long-term alcohol consumption in mice.
复制标题
小鼠长期饮酒后海马形态的变化。
DOI：
10.1126/science.566953
复制
发表时间：
1978
期刊：
影响因子：
56.9
通讯作者：
D. W. Walker
中科院分区：
文献类型：
--
作者：
J. Riley;D. W. Walker
高尔基方法被用来检查实验小鼠的海马体，这些小鼠接受了4个月的含酒精饮食或对照饮食，然后是2个月的无酒精期。长期饮酒可导致大鼠海马锥体细胞和齿状颗粒细胞上树突棘的明显丢失。这项研究提供的证据表明，在没有营养不良的情况下，长期饮酒会对中枢神经系统造成形态损害。
Golgi methods were used to examine the hippocampus of laboratory mice that received alcohol-containing or control diets for 4 months followed by a 2-month alcohol-free period. Long-term alcohol consumption resulted in a significant loss of dendritic spines on hippocampal pyramidal cells and dentate granule cells. This study provides evidence that long-term alcohol consumption, in the absence of malnutrition, produces morphological damage to the central nervous system.